DNP-PEG6-acid
Cat No.: BP-501838
4.5 
DNP-PEG6-acid is a PEG-based linker bearing a DNP (dinitrophenyl) functional group and a terminal carboxylic acid, providing a flexible, hydrophilic chain that is well suited for bioconjugation and PROTAC-related construct assembly. The PEG6 segment acts as a spacer to reduce steric hindrance and to improve solubility, while the terminal acid enables straightforward coupling to amine- or hydrazide-bearing partners through standard carbodiimide or related amide-forming chemistries. In PROTAC design and targeted degradation research, DNP-containing linkers can be used to position a targeting or conjugation handle so that the final degrader can efficiently engage its intended binding partners and promote formation of a productive ternary complex. This product is valuable for researchers seeking modular, chemically tractable linker scaffolds to build and optimize conjugates, screen linker length effects, and tune physicochemical properties that influence degradation efficiency and experimental handling.
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* For research and manufacturing use only. Not for human or clinical use.
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Popular Publications Citing BOC Sciences Products
DNP-PEG6-acid is a polyethylene glycol (PEG)-based PROTAC linker acid designed to connect a targeting ligand and an E3 ligase binder while providing conformational flexibility and improved solubility. Its PEG spacer can reduce steric constraints at the ternary complex interface, supporting efficient ubiquitin-recruitment-driven degradation. The acid functionality enables straightforward conjugation strategies, and the linker is widely used in targeted protein degradation workflows; detailed structural and reactivity considerations are provided below.
Structure: DNP-PEG6-acid features a PEG ether backbone that offers a flexible, hydrophilic spacer, terminating in a carboxylic acid for chemical handle availability. The structure contains ether linkages along the polyether chain and an aromatic DNP-derived moiety, with overall properties consistent with enhanced aqueous compatibility.
Reactivity: The carboxylic acid group is suitable for standard PROTAC linker coupling to amine- or hydroxyl-bearing ligands via amide or ester formation. Typical approaches use acid-activation reagents (for example, carbodiimides with additives) under mild, non-nucleophilic conditions, often in polar aprotic solvents, to form stable linkages while preserving sensitive functional groups. Reaction design should prioritize minimizing hydrolysis and maintaining ligand integrity during conjugation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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