DOTA-PEG5-NH2 hydrochloride
Cat No.: BP-502129
Purity: ≥95%
4.5 
DOTA-PEG5-NH2 hydrochloride is a bifunctional macrocyclic chelator conjugated to a five-unit polyethylene glycol chain terminating in a primary amine. Structurally, it combines the DOTA (1,4,7,10-tetraazacyclododecane tetraacetic acid) core, which forms stable coordination complexes with trivalent metal ions, with a PEG linker that provides aqueous solubility and conformational flexibility while presenting a reactive NH2 handle for further coupling. In PROTAC and targeted degradation workflows, this linker/chelator unit can be used to build modular conjugates where the PEG spacer helps maintain productive geometry between the binding and recruitment elements, and the terminal amine enables attachment to electrophiles or activated carboxyl groups on other components. The DOTA functionality is particularly valuable for researchers who wish to incorporate metal-mediated labeling, imaging, or affinity strategies alongside targeted protein degradation experiments, improving traceability and enabling controlled bioconjugation without substantially perturbing binding interfaces.
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* For research and manufacturing use only. Not for human or clinical use.
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DOTA-PEG5-NH2 hydrochloride is a bifunctional PEG-based linker designed to connect targeting ligands to chelating or conjugation motifs used in targeted protein degradation workflows. Its flexible ethylene glycol segments help tune linker hydrophilicity and spatial presentation, which can improve productive engagement between the recruited binder and the target protein. The amine handle enables reliable coupling chemistries for PROTAC assembly. The detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a poly(ethylene glycol) chain terminating in a primary amine, presented as a hydrochloride salt. It contains ether linkages characteristic of PEG flexibility, with an amine that is protonated under acidic conditions. The DOTA chelator core provides a multidentate coordination framework, enhancing chemical robustness for conjugation strategies.
Reactivity: The terminal amine is suitable for standard amide-forming and urea-forming coupling reactions with activated carboxylic acids or electrophilic carbonyl derivatives. Typical approaches use coupling reagents and base in polar aprotic solvents, while maintaining conditions compatible with PEG stability and the DOTA coordination environment. Mechanistically, nucleophilic substitution at activated intermediates yields stable covalent conjugates for PROTAC construction, with careful control of pH to balance amine reactivity and salt deprotonation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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