DSPE-PEG46-DBCO
Cat No.: BP-502039
4.5 
DSPE-PEG46-DBCO is a DSPE-based, PEGylated bifunctional linker that combines a phospholipid anchor with a long, hydrophilic polyethylene glycol spacer terminated by a DBCO (dibenzocyclooctyne) strained-alkyne handle. Structurally, it features a hydrophobic DSPE moiety that can associate with lipid domains or membrane-like environments, while the extended PEG chain provides aqueous solubility and spatial separation between the conjugated partners. In PROTAC and related targeted degradation workflows, this scaffold is used to introduce a bioorthogonal coupling site that enables efficient, catalyst-free conjugation to azide-bearing ligands or other targeting modules via strain-promoted azide–alkyne cycloaddition. The resulting conjugates can be engineered to control effective molarity, reduce nonspecific interactions, and tune the distance between recognition and functional elements, improving the practicality of modular assembly for degradation constructs. This makes DSPE-PEG46-DBCO valuable for researchers developing membrane-associated or multicomponent targeted protein degradation systems.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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DSPE-PEG46-DBCO is a PEGylated lipid linker designed to enable efficient, modular construction of PROTACs and related targeted degradation platforms via bioorthogonal click chemistry. Its amphiphilic DSPE component supports membrane-associated conjugation and improved handle presentation, while the PEG spacer enhances solubility and flexibility for productive ternary-complex formation. The DBCO functional group provides a highly selective reaction handle for coupling to complementary azide-bearing ligands under mild conditions. Detailed structural and reactivity considerations are provided below.
Structure: The molecule combines a phospholipid (DSPE) anchor with a poly(ethylene glycol) chain and a terminal DBCO cyclooctyne. It contains ether linkages within the PEG segment, a phospholipid headgroup, and a strained alkyne moiety that participates in copper-free cycloaddition. Overall, it is amphiphilic and PEG-rich, favoring aqueous compatibility.
Reactivity: DSPE-PEG46-DBCO is used in strain-promoted azide–alkyne cycloaddition with azide-functional partners, typically proceeding without copper to minimize side reactions. Practical conjugations are performed in aqueous or mixed aqueous buffers at near-neutral pH, often with mild agitation and controlled temperature to preserve sensitive ligands. No additional catalysts are required for the DBCO–azide cycloaddition, though solvent compatibility and ligand stability should be verified for each PROTAC format.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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