m-PEG48-OH
Cat No.: BP-502073
4.5 
m-PEG48-OH is a monodisperse, methoxy-capped polyethylene glycol linker bearing a terminal hydroxyl group, designed for modular conjugation in targeted protein degradation constructs. Its long, flexible PEG chain provides a hydrophilic, sterically accommodating spacer that can reduce non-specific hydrophobic interactions and help tune the effective distance and orientation between a ligand-binding warhead and an E3-recruiting moiety. The terminal hydroxyl enables straightforward functionalization (e.g., conversion to activated derivatives for coupling) while the methoxy cap improves solubility and can mitigate aggregation during synthesis and assay preparation. In PROTAC design, such PEG-based linkers are commonly used to optimize degradation potency and selectivity by balancing linker length, conformational freedom, and cellular permeability-related properties. This product is therefore valuable for researchers seeking reproducible linker scaffolds to systematically evaluate how spacer length and polarity influence ternary complex formation and downstream ubiquitination-dependent degradation.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG48-OH is a methoxy-terminated polyethylene glycol linker designed to provide flexible, hydrophilic spacing in PROTAC architectures. Its ether-rich PEG backbone can improve solubility and help tune the effective distance and conformational freedom between the target-binding ligand and the E3 ligase recruiter. The subsequent points describe its structural characteristics and practical considerations for linker incorporation into targeted protein degradation constructs.
Structure: m-PEG48-OH is a linear PEG chain bearing a terminal hydroxyl group and a methoxy capping group. It is composed primarily of repeating ether linkages, yielding a hydrophilic, flexible scaffold with ether oxygen atoms capable of hydrogen-bonding and solvation.
Reactivity: The terminal hydroxyl enables common PROTAC linker functionalization routes such as conversion to activated carbonate, ester, or ether derivatives for subsequent coupling to amine- or carboxyl-containing ligands. Typical workflows use standard coupling chemistries under inert or controlled conditions, with polar aprotic solvents to maintain PEG solubility. Reaction design generally follows established PEG-linker conjugation principles to preserve linker flexibility and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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