m-PEG4-Ms
CAS No.: 130955-37-2
Cat No.: BP-500351
Purity: ≥98%
4.5 
m-PEG4-Ms is a methoxy-terminated polyethylene glycol linker bearing a mesylate (Ms) leaving group, providing a flexible, water-soluble chain for constructing PROTAC conjugates and other targeted degradation reagents. Structurally, it comprises a short PEG segment with terminal methoxy capping and an activated mesylate at the reactive end, enabling efficient nucleophilic substitution by amines or other suitable nucleophiles to form stable linker–payload or linker–ligand connections. In PROTAC design, this type of PEG linker is used to tune spatial separation and conformational freedom between the E3 ligase–binding moiety and the target-binding ligand, which can improve productive ternary complex formation and thereby influence degradation potency and selectivity. Its PEG-based hydrophilicity also supports better handling in aqueous assay conditions and can reduce nonspecific interactions relative to purely hydrophobic linkers. Overall, m-PEG4-Ms is a practical building block for generating modular PROTAC architectures for systematic structure–activity studies.
Structure of 130955-37-2
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This m-PEG4-Ms linker is designed to serve as a versatile polyethylene glycol-based spacer bearing a mesylate leaving group, enabling efficient conjugation steps commonly used in PROTAC assembly. Its PEG-rich architecture supports solubility and conformational flexibility, while the mesylate functionality facilitates controlled attachment of nucleophilic partners. The combination of a reactive handle and a degraders-friendly linker profile makes it suitable for constructing targeted protein degradation scaffolds. Detailed structural and reactivity considerations are provided below.
Structure: m-PEG4-Ms consists of a methoxy-capped PEG chain terminated with a mesylate (methanesulfonate) ester. The linker contains ether linkages along the PEG backbone and a sulfonate ester at the reactive terminus, providing a polar, hydrophilic scaffold with a good leaving group for substitution.
Reactivity: The mesylate group undergoes nucleophilic substitution under standard PROTAC linker-formation conditions, where suitable nucleophiles (such as amines or thiols) displace the mesylate via an SN2-type pathway. Reactions are typically performed in polar aprotic or mixed solvent systems with base to promote nucleophile formation, and are conducted under conditions that preserve sensitive functional groups. No special catalysts are generally required beyond appropriate base/activation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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