EGFR-IN-5

 CAS No.: 2225887-26-1  Cat No.: BP-300086  Purity: ≥95% 4.5  

EGFR-IN-5 is an inhibitor of EGFR with IC50s of 10.4, 1.1, 34 and 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M and EGFRL858R/T790M/C797S, respectively.

EGFR-IN-5

Structure of 2225887-26-1

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Ligand for Target Protein
Molecular Formula
C31H38FN9O
Molecular Weight
571.69

* For research and manufacturing use only. Not for human or clinical use.

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Purity
≥95%
Solubility
Soluble in DMSO
IUPACName
[1-[6-[[5-[4-(dimethylamino)piperidin-1-yl]pyridin-2-yl]amino]-2-(4-fluoroanilino)pyrido[3,4-d]pyrimidin-4-yl]piperidin-4-yl]methanol
Synonyms
mutant EGFR inhibitor B30; (1-(6-((5-(4-(Dimethylamino)piperidin-1-yl)pyridin-2-yl)amino)-2-((4-fluorophenyl)amino)pyrido[3,4-d]pyrimidin-4-yl)piperidin-4-yl)methanol; 4-Piperidinemethanol, 1-[6-[[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]amino]-2-[(4-fluorophenyl)amino]pyrido[3,4-d]pyrimidin-4-yl]-
Boiling Point
788.2±70.0°C at 760 mmHg
Density
1.4±0.1 g/cm3
InChI Key
DXOUQSZKEPSXBC-UHFFFAOYSA-N
InChI
InChI=1S/C31H38FN9O/c1-39(2)24-11-15-40(16-12-24)25-7-8-28(33-18-25)37-29-17-26-27(19-34-29)36-31(35-23-5-3-22(32)4-6-23)38-30(26)41-13-9-21(20-42)10-14-41/h3-8,17-19,21,24,42H,9-16,20H2,1-2H3,(H,33,34,37)(H,35,36,38)
Canonical SMILES
CN(C)C1CCN(CC1)C2=CN=C(C=C2)NC3=NC=C4C(=C3)C(=NC(=N4)NC5=CC=C(C=C5)F)N6CCC(CC6)CO

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Desired concentration: *

L

* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2

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* Total Molecular Weight:
g/mol
Tip: Chemical formula is case sensitive. C22H30N4O √ c22h30n40 ╳
g/mol
g
Historical Records: TX1-85-1 | OTX015 | PROTAC BTK Degrader-11 | BI-7273 | EED226-COOH | K-Ras G12C-IN-3 | MAK683-CH2CH2COOH | A-1210477 | PD0325901-O-C2-dioxolane | FN-1501 | EGFR-IN-5

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