H2N-PEG12-Hydrazide
Cat No.: BP-501988
4.5 
H2N-PEG12-Hydrazide is a polyethylene glycol–based linker featuring a terminal hydrazide for hydrazone formation and a primary amine at the opposite end, providing a flexible, water-soluble spacer of approximately twelve ethylene glycol units. In PROTAC and targeted degradation constructs, PEG linkers are widely used to tune linker length, conformational freedom, and overall solubility, thereby improving the productive orientation and effective proximity between a ligand that recruits an E3 ligase and a ligand that binds the target protein. The hydrazide functionality enables covalent or reversible conjugation strategies (for example, formation of hydrazone linkages with aldehyde-bearing partners), facilitating modular assembly of degraders and allowing late-stage attachment of targeting or solubilizing modules. This linker is valuable for researchers seeking robust aqueous handling and controlled attachment chemistry when optimizing degrader geometry, minimizing nonspecific interactions, and supporting systematic structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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H2N-PEG12-Hydrazide is a polyethylene glycol (PEG)-based hydrazide linker designed for constructing PROTACs and other targeted protein degradation conjugates. Its PEG spacer provides conformational flexibility and improved solubility, while the hydrazide handle enables reliable coupling to complementary electrophiles used in PROTAC architectures. This molecule will be described in detail below, including its structural characteristics and practical reactivity considerations for linker installation.
Structure: The linker comprises a PEG chain terminated by an amino group and a hydrazide (–C(O)NHNH2) functionality. It contains repeating ether linkages that confer hydrophilicity and segmental flexibility, with amide and hydrazide carbonyl bonding motifs. Overall, it is typically water-compatible and suitable for bioconjugation workflows.
Reactivity: Hydrazides commonly participate in carbonyl-directed coupling and acyl transfer chemistry, including formation of hydrazone linkages with aldehydes under mild conditions. For PROTAC assembly, the hydrazide is used as a nucleophilic coupling partner toward activated carbonyls or aldehyde-functionalized moieties, often in aqueous or mixed solvent systems. Reaction progress is generally monitored by analytical methods, and mild bases or acid catalysis may be selected to control hydrazone formation and stability.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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