H2N-PEG5-Hydrazide
Cat No.: BP-502068
4.5 
H2N-PEG5-Hydrazide is a polyethylene glycol (PEG) linker bearing a terminal hydrazide functionality and an amino group, providing a flexible, water-soluble spacer for bioconjugation workflows. Structurally, it consists of an ethylene glycol repeat chain of moderate length that can reduce steric hindrance and improve solubility of conjugates, while the hydrazide end-group enables formation of hydrazone linkages with aldehyde-containing partners under standard carbonyl–hydrazide chemistry. In PROTAC and targeted degradation designs, such linkers are commonly used to tune the effective distance and relative orientation between a ligand-recruiting moiety and an E3 ligase-binding element, thereby facilitating productive ternary complex formation and improving degradation efficiency. The hydrazone-forming handle also supports modular assembly strategies, allowing researchers to rapidly generate and screen linker variants. Overall, this linker is valuable for constructing chemically defined PROTACs and for optimizing linker length and attachment chemistry in targeted protein degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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H2N-PEG5-Hydrazide is a PEG-based hydrazide linker designed to support targeted protein degradation workflows by enabling stable conjugation between a ligand and an E3-recruiting or target-binding module. Its hydrophilic PEG segment promotes solubility and can help tune linker flexibility, while the hydrazide functionality provides a versatile handle for forming PROTAC-compatible linkages. The detailed structure and reactivity considerations are provided below.
Structure: This molecule contains a terminal amino group attached to a polyethylene glycol chain terminated by a hydrazide moiety. It features ether linkages within the PEG backbone and carbonyl functionality in the hydrazide, offering hydrogen-bonding capacity and improved aqueous compatibility. The overall architecture is flexible and conformationally adaptable.
Reactivity: The hydrazide group can be used for amide-forming conjugation strategies and for coupling workflows that generate PROTAC linkages under standard peptide/amide chemistry conditions. Typical approaches involve activating the complementary carboxyl or carbonyl partner (for example, via carbodiimide-type activation) in suitable polar solvents, followed by nucleophilic acyl substitution. Reaction efficiency depends on pH control and the stability of the partner functional groups during coupling.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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