H2N-PEG6-Hydrazide
Cat No.: BP-502035
4.5 
H2N-PEG6-Hydrazide is a polyethylene glycol (PEG) linker bearing a terminal hydrazide functionality and a primary amine at the other end, providing a flexible, hydrophilic chain that can be used to connect PROTAC components through robust amide or hydrazone-forming chemistries. The PEG6 segment increases solubility and conformational freedom, helping minimize steric clashes between the ligand-binding moieties and the recruited E3 ligase-binding ligand or warhead. The hydrazide group serves as a versatile conjugation handle for forming hydrazone linkages with aldehyde-bearing partners or for coupling to activated carboxylic acid derivatives to generate stable amide linkages, enabling controlled placement of the two binding elements within the PROTAC architecture. In targeted protein degradation research, this type of linker is valuable for tuning linker length and polarity, optimizing ternary complex formation, and improving overall construct stability and handling for iterative design and structure–activity relationship studies.
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* For research and manufacturing use only. Not for human or clinical use.
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H2N-PEG6-Hydrazide is a PEG-based hydrazide linker designed to support efficient conjugation in PROTAC architectures. Its flexible ethylene glycol segment provides favorable solvation and conformational adaptability, while the hydrazide functionality enables formation of stable linkages to complementary warheads. This product is well suited for constructing targeted protein degraders, where linker geometry and chemical compatibility can influence effective ternary complex formation. Detailed structural and reactivity considerations are provided below.
Structure: The linker contains a terminal hydrazide group attached to a poly(ethylene glycol) chain, providing a flexible, hydrophilic scaffold. It features amide and hydrazide-related N–N and C–O/C–N connectivity, with ether linkages along the PEG backbone that promote water compatibility and conformational freedom.
Reactivity: The hydrazide group is typically used in conjugation strategies that form stable amide or hydrazone-derived connections with appropriately functionalized partners. Suitable conditions generally involve mild base or coupling reagents depending on the electrophile, with aqueous or mixed solvent systems to maintain PEG solubility. Mechanistically, nucleophilic attack by the hydrazide on activated carbonyls or aldehyde-derived intermediates enables controlled bond formation, often without requiring harsh catalysts.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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