H2N-PEG8-Hydrazide
Cat No.: BP-501965
4.5 
H2N-PEG8-Hydrazide is a polyethylene glycol (PEG) linker featuring a terminal hydrazide group for covalent conjugation and an amino terminus for controlled attachment to PROTAC scaffolds or other functional handles. The PEG8 chain provides a flexible, water-soluble spacer that helps reduce steric interference between the targeting ligand and the recruited E3 ligase binder, while maintaining sufficient conformational freedom for productive ternary complex formation. In targeted protein degradation workflows, the hydrazide moiety enables formation of hydrazone linkages with aldehyde-functional partners or other carbonyl-reactive conjugation strategies, allowing researchers to modularly connect degraders to warheads, handles, or solubilizing elements. This linker is valuable for optimizing linker length and polarity, improving aqueous handling, and systematically tuning the spatial arrangement that governs degradation potency and selectivity in PROTAC experiments.
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* For research and manufacturing use only. Not for human or clinical use.
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H2N-PEG8-Hydrazide is a PEG-based linker designed to support targeted protein degradation workflows by connecting a hydrazide-reactive handle to PROTAC scaffolds. Its flexible poly(ethylene glycol) chain helps modulate solubility and conformational freedom, while the hydrazide functionality enables chemoselective coupling to complementary partners under standard synthetic conditions. The linker is well suited for constructing degraders where stable conjugation and reproducible linkage chemistry are required; detailed structural and reactivity considerations are provided below.
Structure: The molecule comprises a terminal amino group attached to a poly(ethylene glycol) segment and a hydrazide at the other end. It features ether linkages within the PEG backbone, along with amide and hydrazide functional groups capable of hydrogen bonding and controlled polarity.
Reactivity: Hydrazide groups commonly participate in condensation and acyl-transfer-type conjugation strategies, including formation of hydrazone linkages with carbonyl-containing partners and coupling to activated carboxyl derivatives when appropriate chemistries are selected. Typical approaches use aqueous-organic solvent systems and mild temperatures to preserve linker integrity, with pH control to favor the desired nucleophilic or electrophilic steps.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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