HO-PEG17-OH
CAS No.: 351342-04-6
Cat No.: BP-501448
4.5 
HO-PEG17-OH is a linear, hydroxyl-terminated polyethylene glycol linker with a poly(ethylene glycol) chain length of approximately seventeen ethylene oxide units. Structurally, it provides a flexible, hydrophilic spacer between two reactive handles, typically used to connect a targeting ligand (e.g., an E3-ligase binder) and a warhead or another functional moiety in PROTAC constructs. In targeted protein degradation designs, this PEG spacer helps tune the effective distance and relative orientation of the recruited proteins, reduces steric clashes, and can improve aqueous solubility and handling of conjugates, thereby supporting productive formation of the ternary complex. The two terminal alcohol groups enable straightforward derivatization to common PROTAC-compatible linkages (for example, via activation to form ether/ester or other coupling partners), facilitating modular assembly and systematic SAR studies. As a research tool, HO-PEG17-OH is valuable for optimizing linker length and flexibility to enhance degradation potency and selectivity while maintaining chemical robustness during synthesis.
Structure of 351342-04-6
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HO-PEG17-OH is a polyethylene glycol-based bifunctional linker designed for constructing PROTAC conjugates, enabling flexible spatial separation between targeting and recruiting ligands. Its ether-rich backbone and terminal hydroxyl groups support robust, reproducible chemical coupling strategies commonly used in targeted protein degradation workflows. The linker’s hydrophilicity and conformational adaptability can improve solubility and facilitate productive ternary complex formation. Detailed structural and reactivity considerations are provided below.
Structure: HO-PEG17-OH is a PEG chain bearing terminal primary alcohol functionalities. The backbone consists of repeating ether linkages, providing a flexible, hydrogen-bonding-capable scaffold. As a polyether diol, it is typically water-soluble or water-dispersible and exhibits chemical stability under mild conditions, with reactivity concentrated at the hydroxyl termini.
Reactivity: The terminal hydroxyl groups are suitable for standard PROTAC linker installation via derivatization to activated intermediates, enabling subsequent coupling to amine, carboxyl, or thiol-containing partners. Common approaches include conversion to carbonate/ester/activated ether derivatives using coupling reagents under base and inert or controlled atmospheres, followed by nucleophilic substitution or amide/urea formation. Solvent systems such as polar aprotic media are often used to maintain solubility and drive efficient coupling.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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