HO-PEG22-OH
Cat No.: BP-502099
4.5 
HO-PEG22-OH is a linear, hydroxyl-terminated polyethylene glycol linker featuring an extended ethylene glycol chain that provides a flexible, hydrophilic spacer between PROTAC-relevant functional domains. Its repeating ether units confer conformational mobility and water solubility, helping to reduce steric interference and to tune the effective distance and orientation between the ligand that recruits the target protein and the ligand that engages an E3 ubiquitin ligase. In PROTAC architectures, such PEG linkers can improve productive ternary complex formation by allowing the conjugated warheads to adopt favorable relative positions while maintaining overall solubility of the construct. This product is therefore valuable for researchers optimizing linker length and physicochemical properties in targeted protein degradation studies, particularly when minimizing aggregation and enhancing accessibility of binding interfaces are critical for observing degradation activity in cellular and biochemical assays.
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* For research and manufacturing use only. Not for human or clinical use.
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This HO-PEG22-OH linker is a polyethylene glycol-based diol designed to serve as a flexible spacer in PROTAC architectures. Its ether-rich backbone provides conformational mobility, helping to reduce steric constraints between the target-binding ligand and the E3 ligase ligand. The terminal hydroxyl groups enable straightforward functionalization toward common PROTAC conjugation strategies. The detailed structural and synthetic considerations are provided below to support experimental design and linker incorporation into targeted protein degradation workflows.
Structure: The linker consists of a linear PEG chain bearing terminal primary alcohol functionalities. Its repeating ether units form a flexible, hydrogen-bonding-capable scaffold with ether linkages and hydroxyl groups that promote solubility and conformational averaging in bioconjugates.
Reactivity: The terminal hydroxyl groups are typically used to introduce PROTAC-compatible handles via standard alcohol-to-linker transformations, such as esterification or ether formation with activated electrophiles. Common approaches employ coupling reagents and bases under anhydrous or controlled-humidity conditions, often in polar organic solvents, to generate functional intermediates that can be further coupled to ligands through nucleophilic substitution or acyl transfer pathways.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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