HO-PEG24-OH
CAS No.: 2243942-52-9
Cat No.: BP-501232
Purity: 98%
4.5 
HO-PEG24-OH is a linear, terminally hydroxylated polyethylene glycol (PEG) linker featuring a long ethylene glycol chain that provides a flexible, hydrophilic spacer between PROTAC-binding modules. Its ether-rich backbone confers conformational mobility and solvation, helping to reduce steric interference between the targeting ligand and the E3 ligase recruiter while maintaining sufficient distance for productive ternary complex formation. In PROTAC architectures, PEG linkers are widely used to tune linker length, effective reach, and local microenvironment around the conjugated warheads, thereby influencing ubiquitination efficiency and degradation potency. The two terminal hydroxyl groups enable straightforward chemical functionalization (e.g., conversion to activated derivatives or coupling handles) for attaching to electrophilic or nucleophilic groups on other PROTAC components. As a research-grade spacer, HO-PEG24-OH is valuable for systematic linker optimization, improving solubility and experimental handling of degraders, and supporting structure–activity relationship studies in targeted protein degradation workflows.
Structure of 2243942-52-9
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| 250 mg | $299 | In stock | |
| 1 g | $799 | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
HO-PEG24-OH is a polyethylene glycol-based bifunctional linker designed to support PROTAC assembly by providing a hydrophilic, flexible spacer between a target-binding ligand and an E3 ligase recruiter. Its PEG-rich backbone can help tune solubility and conformational freedom, which are critical for productive ternary complex formation. The detailed structural and reactivity considerations for constructing PROTACs using this linker are provided below.
Structure: HO-PEG24-OH is a linear, bifunctional PEG diol featuring terminal hydroxyl groups connected through repeating ether units. The linker contains predominantly C–O ether linkages, providing high polarity, strong hydrogen-bonding capacity, and flexible conformational behavior. These features typically support aqueous compatibility and stable handling during synthesis.
Reactivity: As a PEG diol, HO-PEG24-OH is commonly incorporated into PROTACs via hydroxyl-reactive coupling strategies. Suitable approaches include converting the terminal alcohols into activated derivatives (for example, carbonate or ester intermediates) or using electrophiles that enable ether/ester formation with complementary functional groups on ligands. Mild bases and polar aprotic solvents are frequently used to promote nucleophilic substitution, while protecting-group strategies can be applied to control chemoselectivity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
