HS-C6-PEG9-acid
Cat No.: BP-502036
4.5 
HS-C6-PEG9-acid is a heterobifunctional, PEG-based PROTAC linker featuring a thioether/thiol-reactive “HS” terminus, a six-carbon alkyl spacer segment, and an extended polyethylene glycol chain that terminates in a carboxylic acid for reliable conjugation chemistry. The PEG segment provides conformational flexibility and aqueous compatibility, helping to reduce steric bias between the two binding modules of a PROTAC while maintaining productive geometry for ternary complex formation. In targeted protein degradation workflows, this linker is used to connect an E3 ligase ligand to a target-binding moiety through amide/ester-forming reactions (from the acid end) and complementary coupling at the thiol-reactive end, enabling controlled spatial separation and improved solubility of the final degrader. Its modular architecture supports systematic linker-length and hydrophilicity optimization, which is critical for tuning degradation potency, selectivity, and experimental reproducibility in cell-based assays.
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* For research and manufacturing use only. Not for human or clinical use.
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HS-C6-PEG9-acid is a polyethylene glycol-based PROTAC linker designed to connect a thiol-functional handle to carboxylate-bearing warheads or ligands. Its flexible PEG segment supports productive ternary complex formation by improving linker solvation and conformational adaptability, while the terminal acid enables robust coupling strategies used in targeted protein degradation workflows. The detailed structural and synthetic considerations are provided below.
Structure: The linker comprises a PEG chain segment providing high conformational flexibility, flanked by a terminal carboxylic acid and a thio-functional group. It contains ether linkages typical of PEG, along with a carboxylate functionality capable of forming amide or ester derivatives under standard coupling chemistries.
Reactivity: The terminal carboxylic acid is suitable for amide bond formation with amine-bearing ligands using peptide-coupling reagents under mild, anhydrous conditions. The thio-functional handle can be employed for thiol–maleimide or thiol–activated electrophile conjugations, enabling modular assembly of PROTAC constructs. Typical solvents include polar aprotic media, and reactions are generally performed under inert atmosphere to minimize thiol oxidation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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