HS-PEG24-CH2CH2COOH
Cat No.: BP-502090
4.5 
HS-PEG24-CH2CH2COOH is a thiol-terminated, long-chain polyethylene glycol (PEG) linker bearing a terminal carboxylic acid that can be used to connect PROTAC components through amide or other carboxyl-reactive chemistries. Structurally, it provides a flexible, hydrophilic spacer with a thioether/thiol handle at one end and a carboxylate-functional group at the other, enabling controlled conjugation while minimizing steric interference between the targeting ligand and the E3 ligase–recruiting moiety. In PROTAC design, such PEG linkers help tune effective molarity, improve solubility, and maintain productive geometry for ternary complex formation by allowing the two binding domains to adopt favorable relative orientations. This linker is therefore valuable for systematic optimization of linker length and polarity in targeted protein degradation studies, supporting reproducible synthesis of conjugates and facilitating downstream biochemical evaluation of degradation potency and selectivity.
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* For research and manufacturing use only. Not for human or clinical use.
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HS-PEG24-CH2CH2COOH is a thiol-terminated, polyethylene glycol-based PROTAC linker designed to connect a ligand-bearing warhead to an E3-recruiting element while promoting favorable solubility and conformational flexibility. Its ether-rich PEG backbone and terminal carboxylic acid enable practical conjugation strategies commonly used in targeted protein degradation workflows. The linker’s balanced hydrophilicity and spacer behavior can help maintain productive ternary complex formation; detailed structural and synthetic considerations are provided below.
Structure: The molecule contains an ether-linked PEG chain terminated by a thiol group and a carboxylic acid-bearing ethyl spacer. Its flexible C–O and C–C linkages, along with an aliphatic thioether/thiol functionality and a terminal carboxyl group, support aqueous compatibility and adaptable reach between binding partners.
Reactivity: The terminal carboxylic acid can be activated for amide or ester formation using standard coupling chemistries (for example, carbodiimide-based activation with an appropriate additive), typically in polar aprotic solvents under controlled pH. The thiol handle is suited to selective thio-conjugation or disulfide exchange strategies, often requiring mild conditions and careful oxidation control. These functional groups are leveraged to assemble PROTAC constructs via stable covalent linkages that preserve linker flexibility.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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