Hydroxy-PEG14-t-butyl ester
Cat No.: BP-501905
4.5 
Hydroxy-PEG14-t-butyl ester is a polyethylene glycol (PEG) linker featuring a terminal hydroxy group and a protected carboxyl functionality masked as a tert-butyl ester. The PEG segment provides a flexible, hydrophilic spacer that can reduce steric interference between a ligand-derived warhead and an E3 ligase–binding module, while the ester handle enables controlled conjugation chemistry for assembling PROTACs or related targeted degraders. In PROTAC design, such PEG-based linkers help tune effective molarity and orientational freedom, thereby improving productive ternary complex formation and promoting ubiquitination-dependent degradation of the target protein. The tert-butyl ester can be used as a synthetic intermediate to introduce the linker into larger constructs and may be cleaved under appropriate conditions to reveal a reactive carboxyl group for downstream coupling. This product is valuable for researchers seeking modular, solubility-enhancing linker architectures to systematically evaluate linker length and attachment geometry in targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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Hydroxy-PEG14-t-butyl ester is a polyethylene glycol-based linker designed to support PROTAC assembly by providing a flexible, hydrophilic spacer while retaining a protected carboxyl functionality for controlled conjugation. Its PEG character can enhance solubility and help tune effective distance and conformational freedom between targeting and recruiting ligands. The subsequent sections describe the linker’s structural features and practical considerations for its use in PROTAC synthesis.
Structure: The linker comprises a PEG backbone terminated by a hydroxyl group and a carboxyl group masked as a tert-butyl ester. It contains repeating ether linkages, providing conformational flexibility and strong hydrogen-bonding capacity, alongside an ester linkage that is stable under mild conditions but readily cleavable under acidic or transesterification conditions.
Reactivity: The tert-butyl ester enables selective coupling strategies where the protected carboxyl is unmasked when needed. For PROTAC construction, deprotection is typically performed under controlled acidic conditions to generate a free carboxylic acid, followed by amide or ester-forming coupling using standard peptide-coupling chemistries. Common solvents include polar aprotic media, and reactions are generally carried out under inert atmosphere to minimize side reactions and maintain linker integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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