Hydroxy-PEG16-acid
Cat No.: BP-502023
4.5 
Hydroxy-PEG16-acid is a polyethylene glycol linker featuring a terminal carboxylic acid and a hydroxyl-functionalized PEG chain of extended length, providing a flexible, hydrophilic spacer for PROTAC architectures. In targeted protein degradation designs, such PEG linkers help tune the spatial relationship between the ligand moieties that recruit an E3 ligase and the target-binding warhead, reducing steric clashes and improving productive ternary complex formation. The carboxylate end enables straightforward conjugation or coupling to complementary functional groups on PROTAC building blocks, while the ether-rich PEG backbone enhances aqueous solubility and can mitigate aggregation and nonspecific hydrophobic interactions. As a result, Hydroxy-PEG16-acid is valuable for researchers optimizing linker length and attachment chemistry to balance binding, degradation potency, and physicochemical properties during iterative PROTAC synthesis and evaluation.
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* For research and manufacturing use only. Not for human or clinical use.
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Hydroxy-PEG16-acid is a polyethylene glycol-based PROTAC linker designed to provide a hydrophilic, flexible spacer between a target-binding ligand and an E3 ligase-recruiting moiety. Its ether-rich PEG architecture supports favorable solubility and conformational adaptability, which can improve productive ternary complex formation in targeted protein degradation workflows. The points below describe the linker’s structural features and practical considerations for PROTAC assembly in research settings.
Structure: The linker is built from repeating ethylene glycol units containing multiple ether linkages, coupled to a terminal carboxylic acid functionality and a hydroxyl terminus. This combination yields a flexible, water-compatible, and chemically stable spacer with hydrogen-bonding capacity that can reduce nonspecific aggregation.
Reactivity: The terminal carboxylic acid enables standard amide or ester-forming coupling routes commonly used in PROTAC synthesis. Typical approaches employ carboxyl-activation chemistry (for example, carbodiimide-based activation with an amine partner) under anhydrous or low-water conditions, often using polar aprotic solvents. The reaction proceeds via formation of an activated carboxyl intermediate, followed by nucleophilic acyl substitution to install the desired conjugation point.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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