Hydroxy-PEG24-CH2-Boc
Cat No.: BP-501871
4.5 
Hydroxy-PEG24-CH2-Boc is a polyethylene glycol–based, hydroxyl-terminated linker featuring an extended PEG chain that is capped with a tert-butyl ester-protected carboxyl functionality. Structurally, the long, flexible ether backbone provides high conformational freedom and aqueous compatibility, while the terminal tert-butyl ester-protected carboxyl group offers a protected handle for subsequent chemical activation or coupling strategies commonly used in PROTAC assembly. In targeted protein degradation designs, PEG linkers are widely employed to tune the spatial separation and relative orientation between the ligand-binding “warhead” modules and the E3-recruiting moiety, thereby improving productive ternary complex formation and reducing steric mismatch. The tert-butyl ester protection supports controlled downstream functionalization under appropriate deprotection conditions, enabling researchers to generate defined conjugation points for attachment to other PROTAC components. This product is valuable for constructing next-generation degraders where linker length, hydrophilicity, and reaction-ready terminal chemistry are critical parameters for systematic structure–activity optimization.
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* For research and manufacturing use only. Not for human or clinical use.
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Hydroxy-PEG24-CH2-Boc is a polyethylene glycol-based PROTAC linker designed to provide a flexible, hydrophilic spacer between a target-binding ligand and an E3 ligase recruiter. Its PEG character supports favorable solubility and conformational adaptability, while the terminal hydroxyl and protected amine functionality enable controlled bioconjugation and stepwise assembly. This molecule is well suited for constructing targeted protein degradation (PROTAC) architectures, and the following points describe its structure and practical reactivity considerations in detail below.
Structure: The linker comprises a repeating PEG ether backbone bearing a terminal hydroxyl group and a methylene spacer connected to a Boc-protected functional handle. It contains multiple ether linkages, a saturated carbon chain segment, and a carbamate protecting group, yielding a flexible, polar, and generally water-compatible scaffold.
Reactivity: The Boc group is typically removed under mild acid conditions to generate a reactive amine for subsequent coupling. PROTAC assembly commonly employs amide or carbamate-forming reactions using activated carboxylic acids or appropriate electrophiles, with base-mediated conditions to promote nucleophilic substitution. Solvent systems such as polar aprotic media or buffered aqueous mixtures are frequently used, and coupling reagents/catalysts are selected based on the target functional group chemistry.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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