Iodo-PEG12-NHS ester
Cat No.: BP-501786
4.5 
Iodo-PEG12-NHS ester is a heterobifunctional polyethylene glycol (PEG) linker combining an NHS ester for amide-bond formation with a terminal iodo group for electrophilic conjugation. Structurally, it is a PEG chain of about twelve ethylene glycol units that provides hydrophilicity, reduced nonspecific interactions, and improved solubility, while the NHS ester reacts with primary amines on targeting ligands (e.g., lysine-containing peptides or amine-bearing small molecules) to install the linker via a stable amide linkage. The iodo functionality enables subsequent coupling to thiols through nucleophilic substitution, allowing sequential or orthogonal assembly of two different molecular components. In PROTAC and targeted protein degradation workflows, such linkers are used to connect a ligand that recruits an E3 ligase to a second ligand that binds the target protein, while the PEG spacer helps tune effective molarity, linker length, and overall physicochemical properties that can influence ternary complex formation and degradation potency. This product is valuable for researchers seeking modular, stepwise synthesis of degraders with controlled conjugation chemistry.
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* For research and manufacturing use only. Not for human or clinical use.
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Iodo-PEG12-NHS ester is a bifunctional polyethylene glycol (PEG) linker designed for modular PROTAC synthesis, combining an NHS-activated ester for efficient amide coupling with a terminal iodo group for orthogonal functionalization. Its PEG spacer supports solubility and provides controlled linker length between targeting ligands, helping preserve binding while enabling reliable conjugation chemistry. The detailed structural and reactivity considerations are provided below.
Structure: The linker contains a PEG chain bearing an N-hydroxysuccinimide (NHS) ester and a terminal iodo substituent. It features an NHS-activated carboxylate for nucleophilic acyl substitution, ether linkages within the PEG backbone, and a carbon–iodine bond suitable for substitution-based coupling.
Reactivity: The NHS ester reacts with primary amines under mild, anhydrous to low-water conditions to form stable amide bonds via acyl substitution. Typical bases include tertiary amines to promote nucleophile formation, using polar aprotic solvents such as DMF or DMSO. The iodo group enables subsequent derivatization through nucleophilic substitution or related coupling strategies, often requiring controlled conditions to maintain orthogonality during stepwise PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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