m-PEG11-Hydrazide
Cat No.: BP-502040
4.5 
m-PEG11-Hydrazide is a mono-functional methoxy-terminated polyethylene glycol (PEG) linker bearing a hydrazide reactive group, providing a flexible, water-soluble spacer of intermediate chain length. Structurally, the PEG segment acts as a hydrophilic “distance” element that can reduce steric interference and improve the effective presentation of conjugation handles when assembling PROTACs or other targeted degraders. The hydrazide moiety enables formation of hydrazone linkages with aldehyde-containing partners, allowing researchers to connect or exchange warhead/ligand components under conditions compatible with downstream synthesis and purification. In PROTAC design, such linkers are commonly used to tune linker length and attachment chemistry to balance ternary complex formation, cellular uptake, and overall degradation efficiency. This product is therefore valuable for constructing modular PROTAC architectures where controlled, chemistry-driven conjugation is required for systematic structure–activity studies.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG11-Hydrazide is a polyethylene glycol (PEG)-based hydrazide linker designed to support PROTAC assembly by providing a flexible, hydrophilic spacer and a reactive hydrazide handle for stable conjugation chemistry. Its PEG character can improve aqueous solubility and can help tune the effective distance and orientation between the target-binding ligand and the E3 ligase-binding element. The hydrazide functionality enables widely used coupling strategies that are compatible with PROTAC workflows, and the details of its structure and practical reactivity considerations are provided below.
Structure: The linker consists of an m-substituted PEG chain terminated with a hydrazide group, featuring ether linkages within the PEG backbone and an amide-derived hydrazide motif. This combination yields a flexible, water-compatible scaffold with hydrogen-bonding capacity and a functional nucleophile for subsequent derivatization.
Reactivity: The hydrazide can participate in conjugation reactions that convert the terminal hydrazide into a targeted attachment point, commonly via carbonyl-activated coupling or hydrazone-forming chemistry with appropriate aldehyde or ketone partners, followed by stabilization when required for PROTAC integrity. Typical conditions use aqueous or mixed aqueous/organic solvents under controlled pH to balance hydrazide nucleophilicity and product stability, with coupling reagents selected to favor chemoselective amide or hydrazone formation.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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