m-PEG12-DSPE
Cat No.: BP-501941
4.5 
m-PEG12-DSPE is a monofunctional amphiphilic PEG–lipid conjugate built from a methoxy-terminated PEG segment conjugated to DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine), providing a PEG–lipid architecture with a flexible hydrophilic spacer and two saturated lipid tails. Structurally, the PEG chain confers aqueous solubility and steric shielding, while the phosphoethanolamine headgroup and hydrophobic DSPE region enable membrane association or incorporation into lipid assemblies. In PROTAC and targeted protein degradation workflows, such PEG–lipid linkers are valuable for formulating degraders into stable nanoscale carriers or for improving effective presentation of bulky conjugates at cell surfaces, thereby enhancing proximity-driven recruitment of target engagement components. This product supports reproducible preparation of lipid-based delivery systems and can help researchers tune circulation-like behavior, reduce nonspecific adsorption, and facilitate cell uptake for experimental evaluation of targeted degradation constructs.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG12-DSPE is a PEGylated phospholipid linker designed to support PROTAC assembly and delivery-related design goals by providing a hydrophilic, flexible spacer and a membrane-active lipid anchor. Its amphiphilic architecture can improve solubility and facilitate formulation strategies that benefit targeted protein degradation workflows. The structure and reactivity considerations are described in detail below to guide experimental use in PROTAC-related conjugation and handling.
Structure: m-PEG12-DSPE consists of a polyethylene glycol chain linked to a DSPE phospholipid headgroup, yielding an amphiphilic molecule with ether-rich PEG segments and phospholipid ester and phosphate functionalities. The linker’s flexible ether linkages and ionic-capable phosphate moiety support water compatibility and self-association behavior.
Reactivity: For PROTAC construction, this linker is typically used in conjugation schemes that exploit phospholipid functional group reactivity or orthogonal coupling handles on the partner ligands. Practical conditions often involve mild, anhydrous-to-semi-aqueous environments to preserve lipid integrity, with coupling chemistries selected to match the functional groups present on the PROTAC warhead and recruiter. Reaction progress is commonly monitored by chromatographic or spectrometric methods, and purification is performed to remove unreacted components.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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