m-PEG13-Boc
Cat No.: BP-501854
4.5 
m-PEG13-Boc is a methoxy-terminated polyethylene glycol (PEG) linker bearing a tert-butyl ester-protected carboxyl group at one end, providing a flexible, hydrophilic spacer for assembling PROTACs and other targeted conjugates. The PEG chain length of approximately thirteen ethylene glycol units and the terminal tert-butyl ester enable controlled synthetic handling: the ester can be cleaved under acidic conditions to reveal a carboxylic acid for subsequent activation and coupling to amine-bearing warhead ligands or E3 ligase–recruiting moieties. In PROTAC design, such PEG linkers help tune the effective distance and relative orientation between the two binding domains, often improving productive ternary complex formation while reducing non-specific hydrophobic interactions through PEG-mediated solvation. This reagent is therefore valuable for researchers optimizing linker length, solubility, and conjugation chemistry in targeted protein degradation workflows, facilitating systematic structure–activity studies and scalable synthesis of modular degraders.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG13-Boc is a polyethylene glycol-based linker bearing a Boc-protected handle, designed to support the modular synthesis of PROTACs by enabling robust conjugation and controlled functional-group manipulation. Its PEG character promotes favorable solubility and flexibility in bifunctional degraders, while the protected amine functionality allows stepwise coupling strategies that minimize side reactions. The detailed structural and synthetic considerations for using this linker in PROTAC construction are provided below.
Structure: The linker consists of a PEG oligomer segment connected to a Boc-protected functional group, providing a flexible, ether-rich backbone. It contains carbonyl and carbamate linkages characteristic of Boc protection, along with ether linkages that confer hydrophilicity and conformational mobility.
Reactivity: Boc groups are typically removed under acid-mediated conditions to generate a free amine for subsequent amide or urea-forming couplings. PROTAC assembly commonly proceeds via carbodiimide-mediated coupling for carboxylic acid partners or nucleophilic acyl substitution where appropriate. Suitable solvents are those compatible with Boc deprotection and coupling chemistries, and reaction monitoring by standard analytical methods is recommended to ensure complete deprotection and minimize overreaction.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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