m-PEG15-NHS ester
Cat No.: BP-501913
4.5 
m-PEG15-NHS ester is a mono-functional methoxy-terminated polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) ester for amide-bond formation. Structurally, it consists of a PEG chain of intermediate length terminated at one end with a reactive NHS group and at the other end with a methyl ether, providing water solubility and a flexible spacer between conjugated partners. In PROTAC and related targeted degradation constructs, this linker is used to covalently attach lysine- or N-terminal amine–containing moieties (for example, ligands or other targeting elements) through stable amide linkages, while the PEG spacer helps reduce steric interference and can improve effective presentation of binding domains. Its value lies in enabling modular synthesis of conjugates with tunable distance and improved handling in aqueous workflows, facilitating systematic structure–activity studies and optimization of ternary-complex formation in targeted protein degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG15-NHS ester is a polyethylene glycol (PEG) based NHS-activated linker designed for efficient conjugation in PROTAC workflows. Its NHS ester functionality enables straightforward coupling to primary amines on targeting ligands, while the PEG spacer improves solubility and can help tune linker flexibility and effective distances between the ligand and recruited E3 ligase. The combination supports modular PROTAC assembly, and the detailed structure and reactivity considerations are provided below.
Structure: The linker comprises an m-substituted aromatic core bearing a PEG chain terminated with an N-hydroxysuccinimide ester. It contains an NHS-activated carboxylate, ether linkages within the PEG segment, and aromatic carbon–carbon and carbon–oxygen bonds. The PEG chain confers hydrophilicity and conformational flexibility.
Reactivity: The NHS ester reacts with primary amines via nucleophilic acyl substitution, forming a stable amide bond while releasing NHS. Coupling is typically performed under mildly basic aqueous or mixed solvent conditions using amine-containing ligands. NHS esters are moisture-sensitive, so fresh solutions and controlled pH are important. No special catalysts are generally required; common bases and buffers are used to maintain amine nucleophilicity without promoting hydrolysis.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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