m-PEG2-azide
CAS No.: 215181-61-6
Cat No.: BP-501284
Purity: 98%
4.5 
m-PEG2-azide is a short, methoxy-terminated polyethylene glycol linker bearing a terminal azide functional group, providing a flexible, water-compatible spacer for bioconjugation chemistry. In PROTAC construction, PEG linkers are commonly used to tune the effective distance and relative orientation between a targeting ligand (e.g., a ligand for an E3 ligase recruiter) and the other binding element, thereby improving productive ternary-complex formation and degradation efficiency. The azide handle enables efficient and selective conjugation via azide–alkyne cycloaddition (CuAAC) or related click approaches, allowing attachment to complementary alkyne-bearing partners under conditions compatible with many biomolecule-derived scaffolds. Its short PEG chain length helps balance solubility and steric control, which can be critical when optimizing linker length for specific protein targets. Overall, m-PEG2-azide is a practical, research-grade building block for assembling modular PROTACs and for rapid linker-optimization studies in targeted protein degradation workflows.
Structure of 215181-61-6
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m-PEG2-azide is a polyethylene glycol-based azide linker designed to support PROTAC assembly through bioorthogonal azide chemistry. Its PEG character promotes solubility and provides a flexible spacer that can improve productive alignment between the targeting ligand and the E3 ligase-recruiting module. The azide handle enables modular conjugation under mild conditions, facilitating rapid linker exchange and systematic structure–activity studies. Detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a short methoxy-terminated PEG chain bearing an azide group at the opposite terminus. It contains ether linkages within the PEG segment and no aromatic core. The terminal azide provides a reactive functional handle while the PEG segment confers hydrophilicity and conformational flexibility.
Reactivity: The azide group is typically used in copper-catalyzed azide–alkyne cycloaddition or related strain-promoted azide reactions, enabling selective formation of a triazole linkage to an alkyne-bearing partner. For copper-catalyzed routes, standard practice employs a copper(I) source with appropriate ligands and aqueous or mixed aqueous solvents under mild temperatures to preserve sensitive ligands. Reaction proceeds via azide activation and cycloaddition, yielding a stable covalent conjugate suitable for PROTAC construction.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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