m-PEG24-Mal
Cat No.: BP-501949
4.5 
m-PEG24-Mal is a monofunctional methoxy-terminated polyethylene glycol (PEG) linker bearing a maleimide group, providing a flexible, water-soluble chain of extended length for PROTAC assembly. Structurally, the PEG segment acts as a hydrophilic spacer that can reduce steric interference between the binding ligands and the recruited E3 ligase, while the maleimide moiety enables selective conjugation to thiol-containing partners via a stable thioether linkage under mild aqueous conditions. In targeted protein degradation designs, this linker is used to connect or functionalize PROTAC components such as ligand-bearing cysteine residues, engineered thiol handles, or other thiol-reactive intermediates, thereby tuning effective molarity, solubility, and the spatial orientation required for productive ternary complex formation. Its utility lies in facilitating reproducible, chemoselective bioconjugation workflows and supporting systematic linker-length optimization in degradation research.
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* For research and manufacturing use only. Not for human or clinical use.
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- Comprehensive PROTAC Platform
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m-PEG24-Mal is a heterobifunctional polyethylene glycol-based linker designed for efficient conjugation in targeted protein degradation workflows. Its maleimide handle enables selective coupling to thiol-containing ligands, while the PEG scaffold provides solubility and improved bioconjugate stability, supporting robust PROTAC assembly and reliable linker behavior in aqueous environments. The following points describe the linker’s structural features and the practical reactivity considerations used during PROTAC construction in detail below.
Structure: The linker comprises a PEG chain terminated with a maleimide electrophile, providing a flexible, hydrophilic spacer and a reactive cyclic imide. It contains carbon–carbon and carbon–oxygen framework bonds within the PEG backbone, with a conjugated maleimide double-bond system that supports thiol addition chemistry. Overall, it is designed for water-compatible conjugation.
Reactivity: Maleimide groups undergo Michael-type addition with free thiols under mildly basic to neutral conditions, forming a stable thioether linkage. Suitable reaction setups typically use aqueous or mixed aqueous buffers that maintain thiol availability while minimizing competing nucleophiles. No special catalysts are required; temperature and pH are adjusted to balance coupling rate and maleimide stability. Thiol-containing building blocks are commonly introduced freshly or protected from oxidation to preserve reactivity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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