m-PEG25-acid
Cat No.: BP-502028
4.5 
m-PEG25-acid is a methoxy-terminated PEG linker bearing a terminal carboxylic acid, providing a flexible, hydrophilic spacer for bioconjugation chemistry. Structurally, it comprises a linear polyethylene glycol chain of intermediate length with a single linkage point at one end, enabling controlled attachment to PROTAC components through standard amide-forming or activated-carboxyl coupling strategies. In PROTAC architectures, such PEG spacers are used to tune the effective distance and conformational freedom between a target-binding ligand and an E3-ligase recruiter, helping to reduce steric clashes, improve productive ternary complex formation, and modulate solubility and handling of the final conjugate. The terminal acid functionality also supports straightforward synthetic diversification during linker optimization. This product is therefore valuable for researchers developing targeted protein degradation constructs that require reproducible, water-compatible linker behavior and reliable chemical handle(s) for assembly and downstream characterization.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG25-acid is a polyethylene glycol (PEG)-based linker acid designed to support PROTAC assembly by providing a flexible, hydrophilic spacer between the target-binding and E3-ligase-binding modules. Its ether-rich backbone can improve solubility and help tune linker length and conformational freedom, which are important determinants of ternary complex formation and targeted protein degradation performance. The details of its structure and practical reactivity considerations for PROTAC synthesis are provided below.
Structure: The linker is an m-PEG scaffold terminated with a carboxylic acid, featuring repeating ether units that confer flexibility and strong hydrogen-bonding capacity. It contains ether linkages and a terminal acid functionality suitable for amide or ester-forming coupling reactions, with PEG-like hydrophilicity supporting favorable handling in polar media.
Reactivity: As a carboxylic acid, it is typically activated for PROTAC conjugation via standard coupling chemistries that form amide bonds with amine-bearing ligands. Common approaches use carbodiimide-based activators and coupling additives in polar aprotic solvents, often under mildly basic conditions to promote nucleophilic acyl substitution. The PEG ether backbone is generally stable under these conditions, enabling reliable linker installation while preserving overall linker integrity.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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