m-PEG3-Mal
Cat No.: BP-502063
4.5 
m-PEG3-Mal is a monofunctional methoxy-terminated polyethylene glycol linker bearing a maleimide group, designed for stable bioconjugation through thiol–maleimide chemistry. The PEG segment provides a short, flexible, hydrophilic spacer that can reduce steric interference and improve effective presentation of the reactive handles when assembling PROTACs or related targeted degraders. In PROTAC workflows, the maleimide moiety enables site-selective coupling to cysteine-containing ligands or thiol-functionalized components, while the PEG chain helps maintain favorable linker dynamics between the two binding domains. This makes m-PEG3-Mal useful for constructing conjugates where controlled attachment, aqueous compatibility, and minimal perturbation of ligand binding are critical. Researchers value it as a practical PEG-based spacer for optimizing linker length and flexibility during iterative PROTAC design and for facilitating modular synthesis of targeted protein degradation reagents.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG3-Mal is a polyethylene glycol (PEG) based maleimide linker designed for efficient conjugation in targeted protein degradation workflows. Its maleimide handle enables selective coupling to thiol-containing ligands, supporting the modular assembly of PROTACs with improved solubility and tunable linker length. The PEG segment can help mitigate aggregation and promote favorable bioconjugate behavior. The following points describe the linker’s structure and practical reactivity considerations in detail below.
Structure: m-PEG3-Mal comprises a PEG chain terminated with a maleimide moiety. The maleimide ring contains an activated alkene within a conjugated imide system, while the PEG backbone provides flexible ether linkages that enhance hydrophilicity and conformational mobility.
Reactivity: The maleimide group undergoes thiol–maleimide Michael addition with free cysteine or other thiol-bearing functional groups under mildly basic aqueous conditions. Conjugation is typically performed using thiol-containing partners generated or maintained in a reduced state, with careful control to minimize competing hydrolysis of the maleimide. No special catalysts are generally required; compatibility with common PROTAC assembly buffers and subsequent purification is commonly used to obtain stable thioether-linked conjugates.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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