m-PEG36-Br
Cat No.: BP-501887
4.5 
m-PEG36-Br is a monofunctional methoxy-terminated polyethylene glycol bromide linker designed for PROTAC and targeted protein degradation workflows that require a flexible, hydrophilic spacer. Structurally, it consists of a linear PEG chain of extended length bearing a terminal bromide, providing a reactive handle for nucleophilic substitution or related conjugation strategies while maintaining distance and conformational freedom between the two binding elements of a degrader. In PROTAC architectures, such PEG linkers help tune the effective geometry and solvent exposure of the warhead and recruiting ligand, often improving productive engagement with the target protein and the E3 ligase by reducing steric constraints. The bromide terminus enables straightforward attachment to complementary nucleophiles, facilitating synthesis of larger conjugates with controlled linker length. This product is therefore valuable for systematic linker optimization, enabling researchers to evaluate how spacer length and hydrophilicity influence degradation potency and cellular performance.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG36-Br is a brominated polyethylene glycol linker designed to support PROTAC assembly through robust, widely used PEG-based conjugation chemistry. Its ether-rich, flexible scaffold helps tune linker length and conformational mobility, which can improve the productive engagement of the target-binding ligand and the E3-recruiting moiety. This product is commonly employed as an electrophilic PEG handle for preparing PROTAC intermediates; the detailed structural and reactivity considerations are provided below.
Structure: The linker consists of a repeating ethylene glycol unit terminated by a terminal bromide, forming an ether-dominated, flexible polymer chain. It contains C–O and C–C bonds characteristic of PEG, with a reactive carbon–bromine bond at the terminus. The material is typically water-compatible and exhibits low polarity-to-protein interaction bias due to PEG shielding.
Reactivity: The terminal bromide enables nucleophilic substitution to install PROTAC fragments bearing suitable nucleophiles such as amines, thiols, or other heteroatom-based nucleophiles. Reaction conditions are generally optimized by selecting polar aprotic solvents and maintaining controlled temperature to balance substitution efficiency and minimize side reactions. Base-assisted alkylation or related coupling strategies are commonly used, with purification typically performed by standard chromatographic or precipitation methods to remove unreacted starting materials and salts.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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