m-PEG37-acid
Cat No.: BP-502020
4.5 
m-PEG37-acid is a monofunctional methoxy-terminated polyethylene glycol (PEG) linker bearing a terminal carboxylic acid, providing a flexible, hydrophilic chain of intermediate length suitable for bioconjugation chemistry. Structurally, the PEG backbone offers conformational mobility and steric shielding, while the terminal acid enables straightforward coupling to amine- or hydrazide-containing partners via standard amide or ester-forming reactions. In PROTAC design, such PEG linkers are commonly used to tune the spatial relationship between a target-binding ligand and an E3 ligase recruiter, helping to optimize productive ternary-complex formation and reduce non-specific interactions. The long, water-soluble linker can also improve handling and solubility of bulky conjugates, facilitating synthesis and downstream characterization. This product is therefore valuable for researchers engineering targeted protein degradation constructs that require controlled linker flexibility, aqueous compatibility, and reliable functional group reactivity for modular assembly.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
m-PEG37-acid is a polyethylene glycol (PEG)-based PROTAC linker designed to provide a hydrophilic, conformationally flexible spacer between a targeting ligand and an E3 ligase-binding moiety. Its ether-rich backbone and terminal carboxylic acid enable reliable conjugation strategies that preserve solubility and can improve productive ternary complex formation. The following points describe the linker’s structure and the practical considerations for assembling PROTAC constructs using this functional handle.
Structure: The linker consists of a repeating PEG ether chain terminated by a carboxylic acid. It contains multiple ether linkages, providing flexibility and strong hydrogen-bonding/solvation capacity. The terminal acid offers a polar functional group suitable for amide or ester-forming coupling, supporting aqueous compatibility.
Reactivity: The carboxylic acid can be activated for nucleophilic acyl substitution, enabling amide bond formation with amine-bearing ligands under standard peptide-coupling conditions. Typical approaches use carbodiimide-based activators with an auxiliary coupling reagent, often in polar aprotic solvents with controlled pH to limit side reactions. The mechanism proceeds via formation of an activated ester/intermediate followed by amine capture, yielding stable PROTAC linkages.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
