m-PEG7-Hydrazide
Cat No.: BP-502009
4.5 
m-PEG7-Hydrazide is a methoxy-terminated, hydrazide-terminated polyethylene glycol linker designed for PROTAC and related targeted protein degradation workflows. The PEG chain provides a flexible, water-soluble spacer that can reduce steric interference between the ligand-binding modules and the recruited E3 ligase moiety, while the terminal hydrazide enables chemoselective conjugation to carbonyl-containing partners (e.g., aldehydes or activated carboxylic acid derivatives) to form stable hydrazone or amide linkages under appropriate conditions. In PROTAC architectures, this linker acts as a modular “molecular tether,” translating the spatial separation required for productive ternary complex formation into a controllable conjugation handle for assembling bifunctional degraders. Its PEG-based length and hydrazide functionality make it useful for optimizing degradation potency and selectivity through systematic linker variation, improving solubility and facilitating downstream synthesis and purification for experimental studies.
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* For research and manufacturing use only. Not for human or clinical use.
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m-PEG7-Hydrazide is a polyethylene glycol (PEG)-based linker designed for conjugation chemistry commonly used in targeted protein degradation workflows. Its hydrazide functionality enables robust coupling to complementary electrophiles or activated carbonyl derivatives, while the PEG spacer supports solubility and flexible presentation of the warhead and E3 ligase-binding module. This product is particularly useful in PROTAC synthesis where linker-mediated geometry and aqueous compatibility can influence productive ternary complex formation; detailed structural and reactivity considerations are provided below.
Structure: The linker comprises a PEG chain terminated with a hydrazide group, providing a flexible, hydrophilic scaffold. It contains ether linkages along the PEG backbone and a terminal hydrazide featuring carbonyl and N–N bonding, enabling hydrogen bonding and stable amide-related connectivity under standard coupling conditions.
Reactivity: Hydrazides typically participate in carbonyl-directed coupling and condensation reactions, including formation of hydrazone linkages with aldehydes or ketones and acyl-derivative mediated amide bond formation via hydrazide activation. PROTAC assembly is commonly performed under mild, aqueous-compatible conditions using appropriate electrophiles, with bases or coupling reagents selected to promote chemoselective reaction while preserving sensitive ligands. Solvent systems are often chosen to balance PEG solubility and reaction kinetics.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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