Mal-NH-PEG14-CH2CH2COOPFP ester
Cat No.: BP-502042
4.5 
Mal-NH-PEG14-CH2CH2COOPFP ester is a heterobifunctional polyethylene glycol (PEG) linker designed for PROTAC and related targeted protein degradation constructs. Structurally, it incorporates a maleimide (Mal) electrophile for rapid thiol–Michael addition, a PEG chain of extended length to provide conformational flexibility and improved aqueous solubility, and an activated carboxylate that can be coupled to amine-bearing ligands to form stable amide bonds. The Mal group enables site-selective conjugation to cysteine-containing protein-binding or targeting modules, while the terminal activated ester supports efficient attachment of the complementary binding element, allowing two ligands to be positioned with appropriate spacing for ternary complex formation. In targeted degradation research, such linkers help tune effective intramolecular reach, reduce steric clashes, and thereby support more reliable engagement of the E3 ligase and target protein. This makes the reagent useful for systematic PROTAC optimization and for generating well-defined, modular degradation probes for experimental evaluation.
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* For research and manufacturing use only. Not for human or clinical use.
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This PROTAC linker, Mal-NH-PEG14-CH2CH2COOPFP ester, is designed to connect a maleimide-bearing handle to PEG-based spacing and an activated ester for efficient conjugation to target-binding ligands. Its flexible, hydrophilic PEG segment can improve solubility and reduce steric constraints, while the maleimide enables selective thiol coupling. The activated ester supports robust amide formation under standard bioconjugation conditions. Detailed structural and reactivity considerations are provided below.
Structure: The linker contains a maleimide electrophile for Michael-type thiol addition, a PEG ether chain that provides conformational flexibility and hydrophilicity, and a terminal activated carboxylate in an ester form. It features amide/ester-compatible functional groups and multiple heteroatoms that support hydrogen bonding and solvation.
Reactivity: For PROTAC assembly, the maleimide typically reacts with suitably positioned thiols via nucleophilic addition to form a stable thioether linkage. The activated ester portion is used to form amide bonds with primary amines on ligands or intermediates. Reactions are commonly performed in aqueous or mixed aqueous buffers at controlled pH, using mild bases or coupling-compatible conditions; catalysts are generally unnecessary for maleimide thiol conjugation, while amide formation may benefit from standard carbodiimide or amine-reactive protocols depending on the ester activation chemistry.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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