Mal-PEG12-DSPE
Cat No.: BP-501955
4.5 
Mal-PEG12-DSPE is a heterobifunctional lipid–polymer conjugate that combines a maleimide reactive group with a long poly(ethylene glycol) spacer terminated by a DSPE (1,2-distearoyl-sn-glycero-3-phosphoethanolamine) lipid anchor. Structurally, it provides a flexible PEG chain of extended length to project the maleimide functionality away from the lipid bilayer, while the DSPE moiety enables stable membrane association through hydrophobic insertion. In PROTAC and targeted degradation workflows, such maleimide–PEG–lipid linkers are valuable for assembling conjugates where a lipid or vesicle-associated component must be brought into proximity with a thiol-bearing ligand or protein-binding module, since maleimides undergo selective thio-Michael addition with cysteine residues or engineered thiols. This facilitates controlled, modular construction of degraders, improves conjugation efficiency, and supports membrane-localized delivery or presentation of degradation machinery in cell-based assays.
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* For research and manufacturing use only. Not for human or clinical use.
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Mal-PEG12-DSPE is a multifunctional amphiphilic PROTAC linker building block that combines a maleimide handle with a PEG spacer and a DSPE lipid anchor. This design supports stable conjugation to thiol-bearing ligands and enables membrane-associated or delivery-oriented architectures, improving effective proximity between the target-binding and E3-recruiting components. The detailed structural and reactivity considerations for constructing PROTAC conjugates are provided below.
Structure: The linker contains a maleimide electrophile for selective thio-Michael addition, a polyethylene glycol segment that enhances hydrophilicity and conformational flexibility, and a DSPE phospholipid motif that imparts amphiphilicity and membrane affinity. It features conjugated carbonyl and alkene functionalities within the maleimide ring, plus ether linkages within the PEG domain.
Reactivity: Maleimide groups typically react with sulfhydryl-containing partners via a thio-Michael addition under mildly basic to neutral aqueous conditions. For PROTAC assembly, thiol-bearing ligands are reacted with the maleimide-functional linker while controlling pH, temperature, and thiol stoichiometry to minimize side reactions such as maleimide hydrolysis. Common approaches use buffered aqueous solvents, with inert atmosphere and freshly prepared thiols to maintain reactivity; no specific catalyst is generally required for the conjugation step.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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