Name: Mal-PEG5-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DCM, DMSO

Appearance

Light Yellow or White Solid

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

Mal-PEG5-CH2CH2COOH; Maleimide-PEG5-CH2CH2COOH; Mal-PEG5-COOH; Mal-PEG5-propionic acid; 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15-pentaoxaoctadecan-18-oic acid; 4,7,10,13,16-Pentaoxaoctadecanoic acid, 18-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-

Boiling Point

549.3±50.0°C at 760 mmHg

Density

1.2±0.1 g/cm3

InChI Key

HFYDLVZXYONWDG-UHFFFAOYSA-N

InChI

InChI=1S/C17H27NO9/c19-15-1-2-16(20)18(15)4-6-24-8-10-26-12-14-27-13-11-25-9-7-23-5-3-17(21)22/h1-2H,3-14H2,(H,21,22)

SMILES

C1=CC(=O)N(C1=O)CCOCCOCCOCCOCCOCCC(=O)O

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	2.5681 mL	12.8403 mL	25.6805 mL
5 mM	0.5136 mL	2.5681 mL	5.1361 mL
10 mM	0.2568 mL	1.2840 mL	2.5681 mL

This Mal-PEG5-acid linker is designed for efficient conjugation in targeted protein degradation workflows, enabling robust attachment of ligands to generate PROTAC constructs. Its PEG-based spacer provides favorable solubility and conformational flexibility, while the maleimide functionality supports selective coupling to thiol-bearing partners under mild conditions. The resulting linkages can improve the practical assembly of degraders and support systematic structure–activity exploration; the following sections describe its structure and reactivity in detail below.

Structure: Mal-PEG5-acid comprises a maleimide electrophile linked to a poly(ethylene glycol) spacer terminating in a carboxylic acid. The maleimide ring contains activated double bonds for thiol addition, while the PEG chain provides ether-rich, flexible connectivity. The carboxyl group offers an anionic handle for downstream coupling and salt formation.

Reactivity: The maleimide group reacts with sulfhydryl-containing nucleophiles via a Michael-type addition to form a stable thioether linkage. Suitable conditions typically use aqueous or mixed aqueous buffers at near-neutral pH, with controlled temperature and exclusion of competing thiols. Common solvents include water, buffered aqueous media, and compatible co-solvents used for solubilizing ligands. No specialized catalysts are generally required; reaction rate and selectivity depend on thiol availability and buffer composition.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂