N-Me-N-bis(PEG4-C2-Boc)
Cat No.: BP-502088
4.5 
N-Me-N-bis(PEG4-C2-Boc) is a PEG-based PROTAC linker building block featuring two PEG4 arms connected through a central N-methylated amide nitrogen, with each arm terminating in a two-carbon spacer bearing a tert-butyl ester-protected carboxyl group. Structurally, its ether-rich PEG segments provide aqueous solubility and conformational flexibility, while the short C2 spacers help position reactive termini for subsequent coupling. In PROTAC architectures, such linkers are used to bridge a target-binding ligand and an E3 ligase recruiter, enabling productive ternary complex formation by tuning distance, relative orientation, and local microenvironment around the recruited proteins. The tert-butyl ester groups protect terminal carboxyl groups that can be deprotected and then activated for controlled coupling strategies during synthesis. This product is valuable for researchers optimizing linker length and flexibility to improve degradation potency, selectivity, and stability in targeted protein degradation workflows.
.gif)
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
This PROTAC linker, N-Me-N-bis(PEG4-C2-Boc), is designed to provide a solubilizing, flexible connection between a ligand and an E3-recruiting or target-binding module. Its PEG-based spacer and protected amine functionality support efficient conjugation workflows while helping maintain favorable physicochemical properties for PROTAC assembly. The features and practical advantages of this linker, including compatibility with common PROTAC synthesis strategies, are described below in detail.
Structure: The linker contains a tertiary amine center (N-Me-N) connected to two PEG4-derived arms terminated with C2 spacers bearing Boc-protected functional groups. It incorporates ether-rich PEG segments that confer hydrophilicity and conformational flexibility, alongside carbamate motifs associated with Boc protection.
Reactivity: Boc-protected sites are typically introduced or retained during earlier coupling steps, then deprotected under standard acidic conditions to reveal reactive amine functionality for subsequent bond formation. PROTAC construction commonly relies on amide or carbamate-forming coupling chemistries, using appropriate coupling reagents and bases in polar aprotic solvents, followed by purification to remove small-molecule byproducts.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
