Name: Mal-PEG6-acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

>95%

Solubility

Soluble in DCM, DMF, DMSO, Water

Appearance

Light Yellow or White Solid

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Shipping

Room temperature in continental US; may vary elsewhere.

IUPACName

3-[2-[2-[2-[2-[2-[2-(2,5-dioxopyrrol-1-yl)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

Mal-PEG6-CH2CH2COOH; Maleimide-PEG6-CH2CH2COOH; Mal-PEG6-COOH; Mal-PEG6-propionic acid; 1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15,18-hexaoxahenicosan-21-oic acid; 21-(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)-4,7,10,13,16,19-hexaoxaheneicosanoic acid; 3,6,9,12,15,18-Hexaoxaheneicosan-21-oic acid, 1-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-; 4,7,10,13,16,19-Hexaoxaheneicosanoic acid, 21-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-

Boiling Point

578.2±50.0°C (Predicted)

Density

1.234±0.06 g/cm3 (Predicted)

InChI Key

PSTLZOHJZGESFU-UHFFFAOYSA-N

InChI

InChI=1S/C19H31NO10/c21-17-1-2-18(22)20(17)4-6-26-8-10-28-12-14-30-16-15-29-13-11-27-9-7-25-5-3-19(23)24/h1-2H,3-16H2,(H,23,24)

SMILES

C1=CC(=O)N(C1=O)CCOCCOCCOCCOCCOCCOCCC(=O)O

ConcentrationVolumeMass	1 mg	5 mg	10 mg
1 mM	2.3071 mL	11.5354 mL	23.0707 mL
5 mM	0.4614 mL	2.3071 mL	4.6141 mL
10 mM	0.2307 mL	1.1535 mL	2.3071 mL

This Mal-PEG6-acid linker is designed for modular attachment of protein-binding ligands in targeted protein degradation platforms, enabling efficient construction of PROTACs with controlled linker length and hydrophilicity. Its maleimide handle supports selective conjugation to thiol-bearing partners, while the terminal carboxylic acid provides a versatile functional group for further coupling strategies. The combination of PEG-based spacing and reactive functionality can improve solubility and facilitate reproducible assembly of degradation constructs; detailed structure and reactivity guidance are provided below.

Structure: Mal-PEG6-acid contains a maleimide electrophile connected to a polyethylene glycol spacer terminating in a carboxylic acid. It features an alkene within the maleimide ring, ether linkages in the PEG chain, and a carboxylate-capable acidic group, contributing to water compatibility and stable conjugation chemistry.

Reactivity: The maleimide moiety undergoes thiol–maleimide conjugation under mild aqueous conditions, typically following Michael addition to form a stable thioether adduct. For PROTAC assembly, thiol-functionalized ligands or intermediates are reacted with the linker in buffered solvent systems while avoiding strong nucleophiles and conditions that promote maleimide hydrolysis. Subsequent coupling can be performed via carboxylic-acid activation using standard amide-forming chemistries.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂