mPEG10-azide
CAS No.: 2112738-12-0
Cat No.: BP-501495
Purity: >95%
4.5 
mPEG10-azide is a methoxy-terminated polyethylene glycol (PEG) derivative bearing a terminal azide group, providing a flexible, hydrophilic linker suitable for bioconjugation. Structurally, it consists of a short PEG chain capped with a methyl ether at one end and an azide functional group at the other, enabling efficient chemical coupling through azide-reactive chemistries such as copper-catalyzed or strain-promoted azide–alkyne cycloaddition. In PROTAC and targeted degradation workflows, this reagent is commonly used to introduce PEG-based spacing between a ligand and a reactive handle, improving solubility, reducing nonspecific hydrophobic interactions, and helping preserve productive geometry for ternary complex formation. The azide handle allows modular attachment to other PROTAC components or to biomolecular targeting moieties, facilitating systematic structure–activity studies. Overall, mPEG10-azide is a practical PEG linker for constructing well-defined, conjugatable degradation reagents with improved aqueous handling and tunable linker architecture.
Structure of 2112738-12-0
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mPEG10-azide is a polyethylene glycol (mPEG)–based azide linker designed for modular synthesis of PROTACs and related targeted protein degradation constructs. Its ether-rich PEG scaffold provides solubility and conformational flexibility, while the azide handle enables efficient chemoselective conjugation to complementary partners. This product is particularly useful for assembling PROTACs under mild conditions to preserve sensitive ligands. The structure and reactivity considerations are described in detail below.
Structure: mPEG10-azide consists of an mPEG chain terminated by an azide functional group. The linker features repeating ether linkages that confer hydrophilicity and flexible segmental motion, along with a terminal carbon–nitrogen–nitrogen–nitrogen motif characteristic of organic azides.
Reactivity: The terminal azide supports copper-catalyzed azide–alkyne cycloaddition and related azide click chemistries, enabling rapid formation of triazole-linked PROTAC architectures. Typical conjugation employs a Cu(I) source generated in situ, an appropriate ligand to control copper speciation, and aqueous/organic mixed solvents at conditions compatible with protein-ligand stability. Alternative strain-promoted azide–alkyne routes can be used to avoid copper when required.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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