mPEG16-bromide
CAS No.: 1238189-11-1
Cat No.: BP-501700
Purity: >95%
4.5 
mPEG16-bromide is a monofunctional methoxy-poly(ethylene glycol) bromide featuring an ether-linked polyethylene glycol chain with a terminal bromide leaving group. Structurally, it is a short PEG linker designed for quantitative conjugation reactions, where the bromide end can be displaced by nucleophiles (for example, amines or thiols) to form stable C–N or C–S bonds, thereby attaching the PEG segment to a target molecule or to a PROTAC intermediate. In PROTAC design, PEG linkers are widely used to tune solubility, reduce nonspecific aggregation, and provide a flexible spacer that can improve productive encounter between the two binding modules while maintaining overall physicochemical balance. As a research reagent, mPEG16-bromide enables controlled PEGylation of ligands or linker fragments, facilitating systematic structure–property studies and optimization of targeted protein degradation constructs.
Structure of 1238189-11-1
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mPEG16-bromide is an activated mPEG linker designed for efficient installation of polyethylene glycol chains onto PROTAC-related small-molecule scaffolds or other targeting motifs. Its bromide leaving group enables straightforward nucleophilic substitution strategies that support modular PROTAC assembly, helping researchers tune solubility, reduce nonspecific interactions, and improve handling of conjugates. The following points describe the linker’s structure and practical reactivity considerations in detail.
Structure: mPEG16-bromide consists of a polyethylene glycol ether chain capped with a terminal bromide, forming a flexible, hydrophilic polyether backbone. The molecule features repeating C–O ether linkages and a primary alkyl bromide at the terminus, which together impart favorable solubility and reactivity.
Reactivity: The terminal bromide participates in nucleophilic substitution reactions commonly used to generate PROTAC intermediates bearing PEG linkages. Suitable conditions typically employ polar aprotic solvents and nucleophiles such as amines, thiols, or carboxylate-derived species to displace bromide via an SN2-type mechanism. Base and temperature are selected to balance nucleophile strength with PEG stability, and catalysts are generally not required for standard alkylation steps.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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