mPEG4-MS
CAS No.: 74654-05-0
Cat No.: BP-501298
Purity: >95%
4.5 
mPEG4-MS is a methoxy-terminated polyethylene glycol–based linker featuring a short PEG chain and a methanesulfonate (mesylate, Ms) leaving group, providing a stable, water-soluble handle commonly used in PROTAC and targeted-degradation workflows. Structurally, the PEG segment acts as a flexible spacer that can reduce steric interference between the two PROTAC-relevant moieties, while the mesylate acts as an electrophilic leaving-group terminus for nucleophilic substitution by suitable amines, thiols, or alkoxides. In PROTAC design, this linker architecture supports modular assembly, allowing researchers to connect a targeting ligand to an E3 ligase–recruiting component or other functional elements while maintaining solubility and improving the effective presentation of binding pharmacophores. Its utility lies in facilitating controlled, reproducible conjugation strategies that are useful for stepwise organic-synthesis workflows and can be used to tune linker flexibility during optimization of targeted protein degradation constructs.
Structure of 74654-05-0
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mPEG4-MS is a polyethylene glycol-based linker designed to support efficient conjugation strategies commonly used in PROTAC assembly workflows. Its PEG character can improve solubility and provide a flexible spacer that helps tune the spatial relationship between ligand modules, supporting productive ternary-complex formation. The following sections describe the structure and practical reactivity considerations for constructing PROTACs using this linker.
Structure: mPEG4-MS comprises an mPEG segment connected to a reactive “MS” functionality, providing a hydrophilic, flexible ether-rich backbone. The molecule contains multiple ether linkages and a terminal electrophilic site suitable for nucleophilic substitution or related coupling chemistry, yielding stable conjugates with improved aqueous compatibility.
Reactivity: The “MS” reactive group is typically used to install the linker onto nucleophilic partners under standard bioconjugation conditions. Suitable approaches involve electrophile–nucleophile coupling, often proceeding via substitution at the activated site. Commonly used solvents include polar aprotic media or buffered aqueous systems, with reaction temperatures and pH selected to preserve sensitive functional groups on the PROTAC ligands. Catalysts are generally not required when the electrophile is sufficiently activated.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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