mPEG4-NH-Mal
CAS No.: 1263044-81-0
Cat No.: BP-501349
Purity: >97%
4.5 
mPEG4-NH-Mal is a methoxy-terminated polyethylene glycol (PEG) four-unit linker bearing a methoxy-capped PEG4 chain connected through an amide linkage to a maleimide (Mal) functional group, enabling stable yet selective conjugation chemistry. Structurally, it provides a short, hydrophilic PEG spacer that can improve solubility and reduce nonspecific interactions while presenting a maleimide handle for thiol–maleimide coupling. In PROTAC and targeted degradation workflows, this linker is valuable for modular assembly: it can be used to attach a PEGylated moiety to a cysteine-containing ligand or other thiol-bearing component, thereby positioning the two binding elements with controlled distance and orientation. The resulting conjugates can be engineered to optimize ternary complex formation and degradation efficiency, while the PEG spacer often helps maintain favorable pharmacokinetic-like properties in vitro assays. This reagent is therefore a practical tool for researchers constructing and tuning targeted protein degraders through robust, chemoselective conjugation.
Structure of 1263044-81-0
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mPEG4-NH-Mal is an mPEG-based maleimide linker designed for chemoselective conjugation workflows commonly used in PROTAC construction. Its maleimide functionality enables efficient coupling to thiol-bearing ligands, supporting modular assembly of targeted protein degraders. The PEG segment improves solubility and can help tune linker hydrophilicity and accessibility, facilitating reproducible synthesis and downstream bioconjugation. Detailed structural and reactivity considerations are provided below.
Structure: mPEG4-NH-Mal contains a polyethylene glycol chain terminated with a maleimide moiety and an amide-linked connection to the PEG segment. It features a cyclic alkene imide (maleimide) capable of Michael-type addition, along with ether and amide linkages that confer hydrophilicity and conformational flexibility.
Reactivity: The maleimide group reacts selectively with thiols via a Michael addition to form a stable thioether linkage. For PROTAC assembly, thiol-containing components are typically generated or introduced under mild aqueous conditions, often buffered to maintain maleimide reactivity while minimizing side reactions. Common solvents include aqueous buffer with compatible cosolvents; catalysts are generally unnecessary, but careful control of pH and thiol stoichiometry is important to preserve selectivity and coupling efficiency.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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