mPEG6-bromide
CAS No.: 125562-29-0
Cat No.: BP-501598
Purity: >96%
4.5 
mPEG6-bromide is a methoxy-poly(ethylene glycol) bromide with a short PEG chain (six ethylene glycol units) terminated by a reactive bromide. Structurally, it provides a hydrophilic, flexible PEG spacer while offering a leaving group for nucleophilic substitution or related ether-forming conjugation strategies. In PROTAC and targeted protein degradation research, such PEG-bromide linkers are commonly used to tune solubility, reduce nonspecific adsorption, and modulate the effective distance and mobility between a targeting ligand and an E3-recruiting or other functional module. The PEG segment can help maintain productive engagement by improving aqueous compatibility and minimizing aggregation, while the bromide enables attachment to nucleophilic handles on partner fragments, facilitating modular assembly of degradation constructs. This product is therefore valuable for constructing well-behaved PROTACs and related bifunctional degraders, particularly when linker hydrophilicity and conjugation efficiency are critical for experimental performance.
Structure of 125562-29-0
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mPEG6-bromide is a polyethylene glycol (mPEG) bromide linker designed to enable ether-linked conjugation steps commonly used in PROTAC and related targeted protein degradation workflows. Its terminal bromide provides a reactive handle for installing mPEG chains onto nucleophilic partners, improving solubility and tuning physicochemical properties that can support reliable PROTAC synthesis and handling. The following sections describe the linker’s structure and the practical reaction logic for constructing PROTAC intermediates in detail below.
Structure: The linker is an mPEG-based alkyl bromide featuring a terminal bromomethyl group attached to a poly(ethylene glycol) chain. It contains ether linkages along the PEG backbone and a carbon–bromine bond at the terminus, yielding a flexible, hydrophilic, and generally water-compatible scaffold.
Reactivity: The terminal bromide can participate in nucleophilic substitution reactions to form stable ether or related alkylated linkages with suitable nucleophiles (for example, phenoxides or alcohol/amine-derived nucleophiles under appropriate conditions). Typical approaches use polar aprotic solvents, controlled base selection to generate the nucleophile, and temperature conditions that favor substitution while minimizing side reactions. No special catalysts are generally required beyond base activation and standard coupling practices used for PEG bromide functionalization.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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