m-PEG10-COOH
CAS No.: 2409969-94-2
Cat No.: BP-500434
Purity: >98%
4.5 
m-PEG10-COOH is a methoxy-terminated polyethylene glycol carboxylic acid linker designed for PROTAC and targeted protein degradation workflows. Structurally, it comprises a PEG chain of intermediate length bearing a terminal carboxyl group, which provides a convenient handle for covalent coupling to ligands or warheads through amide or ester-forming chemistries. In PROTAC architectures, PEG linkers are widely used to tune the spatial relationship between the two binding modules, helping reduce steric clashes and improving productive ternary complex formation by increasing conformational flexibility and solvent exposure. The terminal carboxyl group enables straightforward functionalization during synthesis, allowing researchers to systematically vary linker geometry and hydrophilicity to optimize degradation potency and selectivity. As a modular, water-compatible linker, m-PEG10-COOH supports reproducible conjugate preparation and facilitates structure–activity studies aimed at improving targeted degradation performance in biochemical and cellular assays.
Structure of 2409969-94-2
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m-PEG10-COOH is a polyethylene glycol (PEG) based linker designed to provide solubility, conformational flexibility, and a functional carboxylic acid handle for coupling in PROTAC architectures. Its ether-rich backbone helps improve aqueous compatibility and can reduce nonspecific interactions, supporting efficient assembly of ligand–linker–ligand constructs. The carboxyl group enables robust attachment strategies to E3 ligase binders or targeting ligands, and the following sections describe its structure and practical reactivity considerations in detail below.
Structure: m-PEG10-COOH comprises a PEG chain containing repeating ether linkages terminating in a carboxylic acid. The molecule features flexible C–O ether bonds and a terminal –COOH group suitable for amide or ester formation. Its high polarity and hydrogen-bonding capacity contribute to strong water solubility.
Reactivity: The terminal carboxylic acid is commonly converted to activated intermediates (for example, acid chlorides or activated esters) or directly coupled using standard peptide-coupling chemistries to form amide bonds with amine-bearing PROTAC components. Typical conditions use coupling agents and base in polar aprotic solvents, with temperature control to minimize side reactions. Mechanistically, activation of the carboxyl group enables nucleophilic acyl substitution by an amine to install the linker connection.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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