N-Boc-N-bis-PEG5
CAS No.: 2093154-02-8
Cat No.: BP-501590
4.5 
N-Boc-N-bis-PEG5 is a protected, bis-PEG linker architecture designed for constructing PROTACs and other targeted protein degradation conjugates. Structurally, it contains a Boc-protected nitrogen at one terminus and two polyethylene glycol chains of defined length extending from a central bis-functional core, providing a flexible, hydrophilic spacer that can reduce nonspecific interactions and improve solubility of conjugates. The bis-PEG geometry enables orthogonal attachment of two partners—such as a ligand for an E3 ligase and a ligand or warhead for the target protein—while maintaining sufficient conformational freedom for productive ternary-complex formation. In PROTAC design, this linker mediates the spatial relationship between binding domains, helping tune effective distance and orientation to favor recruitment of the target to the E3 ligase. As a modular, PEG-based scaffold, it is valuable for systematic linker optimization and for generating degraders with improved handling and physicochemical properties for downstream biochemical and cell-based evaluation.
Structure of 2093154-02-8
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This PROTAC linker, N-Boc-N-bis-PEG5, is designed to provide a flexible, water-compatible spacer that can connect two functional partners while supporting productive ternary complex formation. Its PEG-rich architecture helps tune solubility and conformational reach, which are key parameters in targeted protein degradation workflows. The following sections describe its structural features and practical considerations for assembling PROTAC constructs.
Structure: The linker contains a Boc-protected nitrogen core linked to two polyethylene glycol chains, creating a highly flexible, hydrophilic scaffold. Ether linkages within the PEG segments confer conformational mobility, while the carbamate protecting group modulates reactivity and stability during synthesis.
Reactivity: For PROTAC assembly, the Boc group is typically removed under mild acid conditions to expose the reactive amine for subsequent coupling. The exposed amine can then participate in standard amide or urea-forming reactions, commonly using carboxylic acid derivatives or activated electrophiles. Solvent systems are selected to maintain PEG solubility and preserve linker integrity, and coupling steps are generally performed with appropriate base and dehydrating or activating reagents consistent with established peptide-conjugation chemistry.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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