N3-PEG24-Hydrazide
Cat No.: BP-502124
4.5 
N3-PEG24-Hydrazide is a polyethylene glycol (PEG) linker bearing a terminal hydrazide functionality and an azide handle (N3) for orthogonal conjugation. The PEG chain provides a flexible, hydrophilic spacer of extended length that can reduce steric interference between a PROTAC’s binding ligands, improving productive ternary complex formation and enabling more consistent degradation behavior across different target systems. The azide group allows reliable bioorthogonal attachment via azide–alkyne cycloaddition or related click chemistries, while the hydrazide can be used for coupling strategies that generate stable hydrazone or amide linkages depending on the experimental design and partner functional groups. In targeted protein degradation research, this linker is valuable for tuning linker length and attachment geometry, facilitating systematic structure–activity studies, and improving solubility and handling of multicomponent conjugates.
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* For research and manufacturing use only. Not for human or clinical use.
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N3-PEG24-Hydrazide is a polyethylene glycol (PEG)-based PROTAC linker designed to connect an amine-reactive hydrazide handle with complementary targeting and E3 ligase-binding modules. Its flexible, hydrophilic PEG scaffold supports productive ternary complex formation and improved solubility, while the hydrazide functionality enables formation of stable conjugates under commonly used bioconjugation conditions. The following sections describe its structure and practical reactivity considerations for linker installation in targeted protein degradation workflows.
Structure: N3-PEG24-Hydrazide contains a PEG oligomer backbone providing high conformational flexibility and hydrophilicity. The molecule terminates in a hydrazide group, enabling amide/hydrazone-type coupling chemistry, and includes a designated N3 functionality for orthogonal attachment to PROTAC building blocks through established linker-forming reactions.
Reactivity: The hydrazide group is suitable for conjugation strategies that form stable hydrazide-derived linkages, including hydrazone formation with carbonyl-bearing partners followed by appropriate stabilization when required. Typical PROTAC assembly uses mild aqueous or mixed aqueous/organic solvents, controlled pH, and temperature conditions that preserve sensitive ligands. Catalysts are generally not required for hydrazone-type coupling, but reaction monitoring and purification are recommended to ensure complete conversion and minimize side products.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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