NH2-PEG3 hydrochloride
CAS No.: 92505-84-5
Cat No.: BP-501622
4.5 
NH2-PEG3 hydrochloride is a short, amine-terminated polyethylene glycol linker reagent featuring a three-unit PEG chain capped with a primary amine and provided as a hydrochloride salt to enhance handling and aqueous solubility. Structurally, it offers a flexible hydrophilic spacer that can be incorporated into PROTAC constructs to tune the distance and orientation between a ligand-bearing warhead and an E3-ligase recruiting moiety, thereby improving productive ternary complex formation. The terminal amine serves as a versatile conjugation handle for amide coupling, reductive amination, or other standard linker-installation chemistries, enabling controlled attachment to carboxyl- or aldehyde-functional partners. In targeted protein degradation research, such PEG-based spacers are widely used to reduce steric clashes, mitigate non-specific hydrophobic interactions, and improve solubility of conjugates, facilitating synthesis, purification, and downstream biological evaluation.
Structure of 92505-84-5
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NH2-PEG3 hydrochloride is a PEG-based linker building block designed to provide hydrophilicity, conformational flexibility, and reliable attachment chemistry for targeted protein degradation constructs. Its ether-rich poly(ethylene glycol) character helps modulate solubility and reduce nonspecific interactions, while the amine functionality enables straightforward conjugation to ligands used in PROTACs. The following sections describe its structure and practical reactivity considerations for PROTAC assembly.
Structure: The linker consists of a short, ether-containing polyethylene glycol chain terminated by a primary amine and supplied as a hydrochloride salt. It features multiple C–O ether bonds, a protonated amine, and flexible segments that support solvent compatibility and adaptable linker conformations.
Reactivity: As an amine hydrochloride, it is typically used after base-mediated deprotonation to generate the free nucleophile for coupling reactions. Suitable approaches include amide bond formation with activated carboxylic acids (e.g., via common coupling reagents) or nucleophilic substitution where electrophiles are present. Mild aqueous/organic solvent systems and standard inert-atmosphere practices are often employed to preserve PROTAC-ligand integrity and minimize side reactions.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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