NH2-PEG4-Glu(OH)-NH-m-PEG24
Cat No.: BP-501903
4.5 
NH2-PEG4-Glu(OH)-NH-m-PEG24 is a heterobifunctional polyethylene glycol–based PROTAC linker featuring a short PEG4 segment terminated with an amino group, a glutamic acid–derived hydroxylated side-chain element, and a central amide linkage connecting to a long m-PEG24 chain. The combination of a flexible PEG scaffold and a polar, glutamate-like motif provides a water-soluble, conformationally adaptable spacer that can tune the relative positioning of a ligand-recruiting warhead and an E3 ligase binder. In PROTAC architectures, such linkers help maintain productive ternary complex geometry by reducing steric clashes and modulating effective linker length and local polarity, which can strongly influence ubiquitination efficiency. This material is valuable for researchers optimizing targeted protein degradation constructs that require long-range reach and enhanced aqueous handling, enabling systematic linker-length and composition studies to improve degradation potency and experimental robustness.
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* For research and manufacturing use only. Not for human or clinical use.
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This PEG-based linker is designed to connect a protein-binding ligand to an E3-recruiting moiety in PROTAC architectures, providing a flexible, water-compatible spacer that can improve effective reach and conformational freedom. Its hydrophilic polyether character supports solubility and reduces nonspecific hydrophobic interactions, which is advantageous for targeted protein degradation workflows. Detailed structural and synthetic considerations are provided below.
Structure: The molecule is a multi-segment poly(ethylene glycol) framework incorporating an amino terminus, a glutamate-derived hydroxyl-bearing side chain, and an additional amide-linked PEG segment. It contains ether linkages, amide bonds, and a carboxyl-derived functional motif, yielding a highly hydrophilic, conformationally flexible linker.
Reactivity: Linker installation into PROTACs is typically achieved through amide coupling or nucleophilic substitution at the available amino/functional handles, followed by verification of linker integrity. Common approaches use activated carboxylic acid derivatives for amide formation, with base and coupling reagents in polar aprotic or mixed aqueous media. Reaction conditions are selected to preserve PEG integrity and minimize side reactions, and the resulting conjugates are purified to remove unreacted starting materials.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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