Propargyl-PEG14-acid
Cat No.: BP-501794
4.5 
Propargyl-PEG14-acid is a heterobifunctional polyethylene glycol (PEG) linker featuring a terminal propargyl (alkyne) handle and a terminal carboxylic acid, connected through an extended PEG chain that provides a flexible, hydrophilic spacer. The propargyl group enables bioorthogonal coupling chemistries, most commonly copper-catalyzed azide–alkyne cycloaddition (CuAAC), allowing researchers to conjugate this linker to complementary partners such as azide-bearing ligands or handles used in PROTAC assembly. The carboxylic acid provides a reactive functional group for amide-bond formation or other carboxyl-derivatization strategies, facilitating attachment to target-binding or E3 ligase–recruiting modules. In PROTAC design, this linker architecture helps tune effective distance and relative orientation between the two binding moieties, often improving ternary complex formation and degradation efficiency while reducing steric clashes and nonspecific hydrophobic interactions. As a modular PEG spacer, it is valuable for systematic linker optimization and for constructing stable, well-defined conjugates for targeted protein degradation studies.
Assurance
Delivery
Support
* For research and manufacturing use only. Not for human or clinical use.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
- Comprehensive PROTAC Platform
- Scientific Expertise & Technical Support
- Custom Synthesis & Design Service
- Extensive Product Coverage
- Cutting-Edge Innovation
- Fast Delivery & Global Support
- 24/7 customer service
- 100% quality assurance
Popular Publications Citing BOC Sciences Products
Propargyl-PEG14-acid is a polyethylene glycol (PEG)-based PROTAC linker designed to provide a flexible hydrophilic spacer between a warhead and an E3 ligase ligand while retaining a terminal alkyne handle for bioorthogonal conjugation. Its PEG character supports solubility and can help tune effective distance and orientation in ternary complex formation, which are key determinants of targeted protein degradation efficiency. Detailed structural and synthetic considerations are provided below.
Structure: The linker comprises a PEG chain terminated with a propargyl group and a carboxylic acid. It contains ether linkages along the PEG backbone, a terminal alkyne for click-type coupling, and a carboxyl group suitable for amide or ester formation. Overall, it is flexible and highly polar.
Reactivity: The terminal alkyne enables copper-catalyzed azide–alkyne cycloaddition for assembling PROTACs bearing azide-functional partners, typically using Cu(I) sources under standard click conditions. The carboxylic acid can be activated to form amide bonds with amine-bearing ligands using common coupling chemistries. Mechanistically, conjugation proceeds via alkyne cycloaddition or acyl activation followed by nucleophilic substitution, with polar solvents often used to maintain PEG solubility.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
Related Product Recommendations
Please contact us with any specific requirements and we will get back to you as soon as possible.
