S-acetyl-PEG20-alcohol
Cat No.: BP-501907
4.5 
S-acetyl-PEG20-alcohol is a PEG-based linker bearing a terminal hydroxyl group and an S-acetyl thioester functionality, providing a chemically versatile scaffold for constructing PROTACs and other targeted protein conjugates. Structurally, it combines a long, flexible poly(ethylene glycol) chain with an acyl-protected sulfur handle that can be used to introduce or modulate attachment points while maintaining solubility and conformational freedom. In PROTAC design, such linkers help position the two binding modules by acting as a spacer, reducing steric clashes and enabling productive formation of the ternary complex between an E3 ligase recruiter and the target ligand. The PEG segment can also improve aqueous compatibility and reduce nonspecific aggregation, supporting more reliable synthesis and downstream biochemical evaluation. As a modular building block, it is valuable for researchers optimizing linker length, flexibility, and conjugation chemistry to tune degradation potency and selectivity in targeted protein degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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S-acetyl-PEG20-alcohol is a PEG-based linker building block designed to support the synthesis of PROTACs by providing a flexible, hydrophilic spacer that can improve solubility and modulate the effective distance between the target-binding ligand and the E3 ligase-recruiting moiety. Its acetyl-protected alcohol functionality enables controlled derivatization, facilitating attachment strategies commonly used in targeted protein degradation workflows. The detailed structural and reactivity considerations are provided below.
Structure: The linker consists of a poly(ethylene glycol) chain terminated with an acetyl-protected alcohol, featuring repeating ether units that confer strong hydrogen-bond acceptor character and conformational flexibility. The molecule contains ester functionality from the acetyl group and ether linkages along the PEG backbone, supporting favorable aqueous compatibility and stable covalent attachment points.
Reactivity: The acetyl-protected alcohol is typically handled under conditions that preserve the ester during coupling, followed by selective deprotection when an alcohol or related reactive handle is required for PROTAC assembly. Common approaches include ester deprotection using mild base or nucleophilic conditions compatible with PEG ethers, and subsequent functional-group activation for bond formation to ligands. Solvent systems such as polar aprotic or alcohol-containing media are often used to ensure PEG solubility and efficient coupling, while reaction temperatures are chosen to maintain linker integrity and minimize PEG cleavage.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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