SPDP-PEG5-acid
Cat No.: BP-502016
4.5 
SPDP-PEG5-acid is a heterobifunctional polyethylene glycol linker bearing an activated disulfide group derived from the SPDP (pyridyldithio) motif and a terminal carboxylic acid for stable attachment to PROTAC scaffolds or other targeting moieties. Structurally, it provides a short PEG chain that increases aqueous solubility and spatial separation, while the disulfide enables reversible thiol exchange with cysteine-containing ligands or thiol-functionalized intermediates to form a new thioether linkage under standard conjugation conditions. In PROTAC design, this linker is used to couple a ligand or warhead to a second component that will engage an E3 ligase or recruiting module, with the PEG spacer helping to reduce steric hindrance and improve productive ternary-complex formation. Its value for targeted protein degradation research lies in offering a controllable, modular conjugation handle that supports reproducible synthesis of conjugates for biochemical and cellular degradation studies.
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* For research and manufacturing use only. Not for human or clinical use.
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SPDP-PEG5-acid is a PEG-based bifunctional linker designed for constructing PROTACs and other targeted conjugates through orthogonal thiol-reactive and carboxylate-bearing handles. Its flexible poly(ethylene glycol) segment supports productive spatial presentation of ligands to enable efficient formation of ternary complexes. The linker’s functional groups facilitate modular synthesis and downstream coupling, providing a practical platform for researchers who require controlled attachment chemistry. Detailed structural and reactivity considerations are provided below.
Structure: SPDP-PEG5-acid contains a polyethylene glycol chain that imparts conformational flexibility, with an acid functionality for carboxylate chemistry and an SPDP-derived disulfide-reactive motif for thiol-mediated conjugation. The molecule features ether linkages along the PEG backbone and a disulfide element enabling reversible thiol exchange.
Reactivity: The disulfide-containing SPDP motif reacts with primary thiols under mild aqueous or mixed-solvent conditions to generate a new disulfide-linked conjugate via thiol–disulfide exchange. Carboxylate chemistry enables coupling to amine-bearing partners using standard amide-forming strategies. Typical workflows use thiol-compatible buffers, controlled pH, and freshly prepared thiol reagents; catalysts are generally not required for the exchange step, while coupling steps may use conventional coupling reagents.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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