t-Boc-Aminooxy-PEG12-acid
Cat No.: BP-501737
4.5 
t-Boc-Aminooxy-PEG12-acid is a functionalized polyethylene glycol (PEG) linker featuring a terminal aminooxy group protected as a tert-butoxycarbonyl (t-Boc) carbamate and a carboxylic acid at the opposite end. Structurally, it provides a flexible, water-soluble, long-chain spacer that can be used to connect PROTAC components while minimizing steric interference and improving effective molarity at the protein-binding interfaces. In targeted protein degradation designs, the aminooxy functionality enables chemoselective oxime or related conjugation strategies with carbonyl-bearing partners, allowing researchers to install the linker between an E3 ligase ligand and a target-binding moiety or to attach the linker to a prefunctionalized warhead. The PEG12 length and terminal handles make it particularly useful for tuning linker reach, solubility, and degradation potency in modular PROTAC synthesis workflows, supporting systematic structure–activity relationship studies in vitro.
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* For research and manufacturing use only. Not for human or clinical use.
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This PROTAC linker, t-Boc-Aminooxy-PEG12-acid, is designed to provide a chemically addressable aminooxy handle together with a PEG-based spacer and a carboxylic acid functional group. Its flexible, hydrophilic architecture can improve solubility and help tune the effective distance between ligand-binding elements in targeted protein degradation constructs. The detailed structural and synthetic considerations for building PROTACs with this linker are provided below.
Structure: The molecule contains a Boc-protected aminooxy moiety linked to a poly(ethylene glycol) chain and a terminal carboxylic acid. It features ether linkages within the PEG segment, an aminooxy functional group, and ester/amide-forming potential at the acid. Overall, it is a hydrophilic, flexible scaffold with polar functional sites.
Reactivity: The aminooxy group enables oxime or related carbon–heteroatom bond formation under standard oxime-chemistry conditions, typically using an aldehyde or ketone partner to drive condensation. The t-Boc group can be removed to reveal the reactive aminooxy functionality when needed. The carboxylic acid can be activated with a suitable coupling reagent and then reacted with an amine-containing partner to form a stable amide linkage, facilitating PROTAC assembly.
* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C1V1 = C2V2
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