Name: t-Boc-N-amido-PEG4-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Size

Price

Stock

Quantity

$--

In stock

Purity

≥95%

Solubility

Soluble in DMSO (10 mm)

Appearance

Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C

Shipping

Room temperature, or blue ice upon request.

IUPACName

3-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid

Synonyms

t-Boc-N-amido-PEG4-acid; 15-(Boc-amino)-4,7,10,13-tetraoxapentadecanoic acid; 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic acid; (Boc-amino)-PEG4-carboxylic Acid; Boc-NH-PEG4-CH2CH2COOH; t-Boc-NH-amido-PEG4-COOH; Boc-NH-PEG4-COOH; N-(tert-Butyloxycarbonyl)-15-amino-4,7,10,13-tetraoxapentanedecanoic Acid; 5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(1,1-dimethylethyl) ester

Boiling Point

504.5±50.0 °C at 760 mmHg

Density

1.124±0.06 g/cm3 at 20°C, 760 Torr

InChI Key

YEIYIPDFZMLJQH-UHFFFAOYSA-N

InChI

InChI=1S/C16H31NO8/c1-16(2,3)25-15(20)17-5-7-22-9-11-24-13-12-23-10-8-21-6-4-14(18)19/h4-13H2,1-3H3,(H,17,20)(H,18,19)

SMILES

CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)O

Biological Activity

Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. Boc-NH-PEG4- CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

t-Boc-N-amido-PEG4-propionic acid, provides a PEG-based, amide-containing spacer that supports controlled spatial separation between targeting and recruiting ligands. Its protected carboxyl functionality and amide linkage enable modular synthesis of degraders, improving conjugation flexibility and often enhancing solubility and linker processability in PROTAC workflows. The detailed Structure and Reactivity parameters are provided below.

Structure: The molecule contains a poly(ethylene glycol) chain that confers hydrophilicity and conformational flexibility, terminated by a propionic acid motif. An amide linkage connects the PEG segment to the carbonyl framework, while a t-Boc group provides acid/base-stable protection for downstream coupling chemistry.

Reactivity: The protected carboxylic acid and t-Boc group are designed for stepwise PROTAC assembly. Deprotection under standard Boc-removal conditions generates a free amine or carboxyl handle (depending on synthetic design), enabling amide or ester-forming coupling to ligand scaffolds. Common coupling strategies employ activated carboxylic acids (e.g., carbodiimide or uronium-type reagents) in polar aprotic solvents, with base to promote nucleophilic acyl substitution.

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* Our calculator is based on the following equation:
Concentration (start) x Volume (start) = Concentration (final) x Volume (final)
It is commonly abbreviated as: C₁V₁ = C₂V₂