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t-Boc-N-amido-PEG4-propionic acid - CAS 756525-91-4

Inquiry

Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Boc-NH-PEG4-CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC).

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Molecular Formula

C16H31NO8

Molecular Weight

365.42

t-Boc-N-amido-PEG4-propionic acid

- Specification
  - Related CAS
    
    187848-68-6 (polymer)
    
    Purity
    
    ≥95%
    
    Solubility
    
    Soluble in DMSO (10 mm)
    
    Appearance
    
    Pale Yellow or Colorless Oily Matter
    
    Storage
    
    Store at 2-8°C
    
    Shipping
    
    Room temperature, or blue ice upon request.
    
    IUPAC Name
    
    3-[2-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
    
    Synonyms
    
    t-Boc-N-amido-PEG4-acid; 15-(Boc-amino)-4,7,10,13-tetraoxapentadecanoic acid; 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azaicosan-20-oic acid; (Boc-amino)-PEG4-carboxylic Acid; Boc-NH-PEG4-CH2CH2COOH; t-Boc-NH-amido-PEG4-COOH; Boc-NH-PEG4-COOH; N-(tert-Butyloxycarbonyl)-15-amino-4,7,10,13-tetraoxapentanedecanoic Acid; 5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(1,1-dimethylethyl) ester
- Properties
  - Boiling Point
    
    504.5±50.0 °C at 760 mmHg
    
    Density
    
    1.124±0.06 g/cm3 at 20°C, 760 Torr
    
    InChI Key
    
    YEIYIPDFZMLJQH-UHFFFAOYSA-N
    
    InChI
    
    InChI=1S/C16H31NO8/c1-16(2,3)25-15(20)17-5-7-22-9-11-24-13-12-23-10-8-21-6-4-14(18)19/h4-13H2,1-3H3,(H,17,20)(H,18,19)
    
    Canonical SMILES
    
    CC(C)(C)OC(=O)NCCOCCOCCOCCOCCC(=O)O
    
    Biological Activity
    
    Boc-NH-PEG4-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1]. Boc-NH-PEG4- CH2CH2COOH is also a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

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